Can calcium channel blockers cause indigestion?
Calcium Channel Blockers They work by relaxing smooth muscles around blood vessels. Since the LES is made up of smooth muscle, calcium channel blockers often relax it, leading to heartburn. If you take one of these medicines and have frequent heartburn, don’t stop taking it, but let your doctor know.
Why do calcium channel blockers cause GERD?
Recent studies suggest that calcium channel blockers (CCBs), and particularly nifedipine, increase the risk of GERD by significantly reducing the tone of the LES, increasing esophageal exposure to gastric acid and reducing the amplitude and duration of esophageal peristalsis [6–8].
Can amlodipine cause dyspepsia?
It is one of the most widely prescribed anti-hypertensive agents. The reported chronic gastrointestinal side effects from amlodipine include constipation, dyspepsia, dysphagia, diarrhea, flatulence and pancreatitis.
Why does amlodipine cause GERD?
Some medications may also lead to symptoms of GERD. These may relax the LES or may increase gastric acid secretion. They include: calcium-channel blockers (e.g. Amlodipine, Nifedipine etc.
Does diltiazem cause stomach problems?
Tell your doctor immediately if any of these rare but very serious side effects occur: severe stomach/abdominal pain, dark urine, persistent nausea/vomiting, yellowing eyes/skin. A very serious allergic reaction to this drug is rare.
Does diltiazem cause reflux?
Conclusions: Diltiazem appears the least likely of the CAs to precipitate or exacerbate reflux symptoms.
Does diltiazem cause acid reflux?
Does amlodipine cause GERD?
With the exception of diltiazem, a statistically significant increase in symptoms was shown for the remaining CAs. Overall, the DHPs were the most frequent contributors to symptom exacerbation, with acid reflux and heartburn exacerbated by amlodipine and chest pain by nifedipine (Table 5).
Can amlodipine upset your stomach?
SIDE EFFECTS: Dizziness, lightheadedness, swelling ankles/feet, nausea, abdominal/stomach pain, or flushing may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Can amlodipine give you indigestion?
Abdominal pain. Feeling sick. Disturbances of the gut such as indigestion, diarrhoea or constipation. Fluid retention that causes swelling, for example swollen ankles (oedema).
Does amlodipine besylate cause indigestion?
Are there any calcium channel antagonists that are contraindicated?
Calcium channel antagonists are also contraindicated in patients with known hypersensitivity to the drug or its components. Other contraindications include sick sinus syndrome (except in patients with an artificial pacemaker), severe hypotension, acute myocardial infarction, and pulmonary congestion.
How are nitrates and calcium antagonists related to angina?
Since nitrates and calcium antagonists (Cas) are known to decrease the lower oesophageal sphincter (LOS) pressure in a dose-dependent manner, and impair oesophageal clearance, frequent angina or a worsening in its severity could result from reflux induced by antianginal therapy [6].
How are calcium channel antagonists work in the heart?
Mechanism of Action Calcium channel antagonists block the inward movement of calcium by binding to the L-type “long-acting” voltage-gated calcium channels in the heart, vascular smooth muscle, and pancreas. There are two major categories of calcium channel antagonists based on their primary physiologic effects.
Can a calcium blocker cause gastroesophageal reflux disease?
This condition, known as gastroesophageal reflux disease, or GERD, can sometimes be brought on or made worse by medications. One such class of medications is calcium channel blockers, or CCBs.