What are quinoline derivatives?
Quinoline has several anti-malarial derivatives, including quinine, chloroquine, amodiaquine, and primaquine. Quinolines are reduced to tetrahydroquinolines enantioselectively using several catalyst systems.
What is the function of quinoline?
Quinoline is used principally for the manufacture of nicotinic acid, which prevents pellagra in humans, and other chemicals. Several methods are known for its preparation, and production of synthetic quinoline exceeds that from coal tar.
What is primaquine quinoline derivative?
Primaquine. Primaquine, an 8-aminoquinoline derivative, is effective against the intrahepatic permanent forms of Plasmodium vivax and Plasmodium ovale. It is used for the complete elimination of pathogens in combination with a blood schizontocide for the erythrocytic parasites.
How do you make Quinolines?
Quinolines may be obtained by the Skraup synthesis. This involves heating aniline or a substituted aniline with glycerol in the presence of sulphuric acid, ferrous sulphate and nitrobenzene. The reaction is complex. It involves dehydration of glycerol by means of sulphuric acid to give acrolein.
Which moiety is present in Quinolines?
pyrazole moiety
Thus, these studies suggest that quinoline derivatives bearing pyrazole moiety are interesting scaffolds for the development of novel antibacterial and antifungal agents. Keywords: Antibacterial and antifungal agents; Pyrazoles; Quinolines.
Is chloroquine a derivative of quinoline?
The quinolines mefloquine, chloroquine and related compounds are well-established antimalarials (Brocks and Mehvar, 2003; Milner et al., 2010).
Is quinoline a base?
Quinoline is a weak tertiary base. It can form salt with acids and displays reactions similar to those of pyridine and benzene.
Which of the following drug is 4-aminoquinoline derivative?
The four aminoquinoline antimalarial drugs are schizontocidal and gametocytocidal in nature. The four aminoquinolines include chloroquine, amodiaquine, and piperaquine. Primaquine, which is an eight aminoquinoline, acts against hypnozoites.
Why is quinoline less basic than pyridine?
The positive charge of quinoline on the nitrogen is harder to solvate due to steric repulsion of the nearby ring, whereas in pyridine, the small hydrogen atoms in place do not pose a strong steric hindrance for the solvation of the ion.
Which of the following drug contains a quinoline ring?
Quinolines
| Drug | Drug Description |
|---|---|
| Chloroquine | An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. |
| Amodiaquine | An antimalarial drug. |
| Trovafloxacin | An antibiotic used to treat gonorrhea and chlamydia. |