What structures tell us about chemokine receptor function and antagonism?
In parallel, chemokine receptor structures with small molecules reveal the complicated and diverse structural foundations of small molecule antagonism and allostery, highlight the inherent physicochemical challenges of receptor:chemokine interfaces, and suggest novel epitopes that can be exploited to overcome these …
What is the meaning of chemokine receptors?
Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine. This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism.
What family of proteins do chemokine receptors belong to?
G protein-coupled receptors
Chemokine receptors are members of the family of 7-transmembrane spanning, G protein-coupled receptors. Differential expression of chemokine receptors correlates with tissue-specific homing and directional migration of leukocytes.
What is the function of chemokine receptors?
ARE IEL GOVERNED BY UNIQUE MOLECULAR INTERACTIONS?
| Receptor (IEL) | Function | Ligand Type |
|---|---|---|
| Homing | ||
| αEβ7 integrin | Adhesion to epithelium | Adhesion molecule |
| CCR9 chemokine receptor | Migration to the small intestine | Chemokine made by thymus and small intestine |
| Regulation |
What is the main function of chemokines?
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are best known for their ability to stimulate the migration of cells, most notably white blood cells (leukocytes).
What are chemokines in immunology?
Chemokines are a large family of small cytokines and generally have low molecular weight ranging from 7 to 15kDa. Chemokines and their receptors are able to control the migration and residence of all immune cells.
What are the differences between cytokines and chemokines?
A cytokine and a chemokine are both small proteins made by cells in the immune system. Cytokines are the general category of messenger molecules, while chemokines are a special type of cytokine that direct the migration of white blood cells to infected or damaged tissues.