What is NK T-cell lymphoma?
Extranodal NK/T-cell lymphoma, nasal type, is a rare fast-growing (high-grade) non-Hodgkin lymphoma that grows outside the lymphatic system (‘extranodal’), usually in the nose (‘nasal’). It can develop from two different kinds of lymphocyte (white blood cell):
Is NK T-cell lymphoma curable?
In the retrospective International Peripheral T-cell Lymphoma Project, the median overall survival among patients with ENKL was 3 years for localized and 8 months for advanced disease. Despite the short median overall survival, with most current treatment approaches, a significant number of patients are cured.
How do you treat nasal NK lymphoma?
Nasal NK/T-cell lymphomas present mostly with stage I/II disease. Concomitant/sequential chemotherapy and radiotherapy is standard treatment. Radiotherapy alone is inadequate because of high systemic failure rate. For stage III/IV nasal, nonnasal, and disseminated lymphomas, systemic chemotherapy is indicated.
What is the survival rate for T-cell lymphoma?
5-year relative survival rates for NHL
| SEER Stage | 5-Year Relative Survival Rate |
|---|---|
| Localized | 96% |
| Regional | 90% |
| Distant | 85% |
| All SEER stages combined | 89% |
Can you get lymphoma in the nose?
Lymphomas (cancers starting in immune system cells called lymphocytes) can occur in the nasal cavity and paranasal sinuses and are the third most common cancer found in this area. One type of lymphoma seen in this area, T-cell/natural killer cell nasal-type lymphoma, was previously called midline lethal granuloma.
Is NK T-cell lymphoma hereditary?
Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study. which was done in an east Asian population, showed that rs9277378, a single-nucleotide polymorphism (SNP) on HLA-DPB1, was associated with the genetic risk of NKTCL development.
What is aggressive NK cell leukemia?
Aggressive NK-cell leukemia (also called aggressive NK-cell lymphoma, or ANKL, is a very rare type of NHL. The body makes large numbers of NK cells that are larger than normal. It is grouped with T-cell lymphomas. ANKL develops most often in people from Asia, Central America and South America.
How do you know if you have a nose tumor?
Signs and symptoms of nasal and paranasal tumors can include: Difficulty breathing through your nose. Loss of the sense of smell. Nosebleeds.
What does extranodal lymphoma mean?
The term extranodal disease refers to lymphomatous infiltration of anatomic sites other than the lymph nodes. Almost any organ can be affected by lymphoma, with the most common extranodal sites of involvement being the stomach, spleen, Waldeyer ring, central nervous system, lung, bone, and skin.
Is T cell lymphoma bad?
Cutaneous T-cell lymphoma (CTCL) is a rare type of cancer that begins in white blood cells called T cells (T lymphocytes). These cells normally help your body’s germ-fighting immune system. In cutaneous T-cell lymphoma, the T cells develop abnormalities that make them attack the skin.
Which is worse B-cell or T-cell lymphoma?
Peripheral T-cell lymphomas have a worse prognosis than B-cell lymphomas: a prospective study of 361 immunophenotyped patients treated with the LNH-84 regimen.
What kind of disease is nasal NK T cell lymphoma?
Nasal NK/T-cell lymphoma (NKTCL) is an uncommon disease, but usually shows a highly aggressive clinical course. The disease is much more frequent in Asian and Latin American countries than in Western countries, and is universally associated with Epstein–Barr virus (EBV) infection.
Where does NK / T cell lymphoma usually occur?
Although the upper respiratory tract, especially nasal region, is the common site of presentation, NK/T-cell lymphoma of nasal type may present in diverse extranodal sites such as gastrointestinal tract, skin, testis, liver, and spleen [16].
What kind of cancer is extranodal nasal lymphoma?
Summary Summary. Extranodal nasal NK/T cell lymphoma (NKTCL) is a rare type of cancer. The term extranodal is used because this form of lymphoma is found outside of the traditional lymph node groupings.
What is the prognosis for nasal lymphoma?
Like many other lymphomas of T-cell origin, nasal lymphoma is often a highly aggressive cancer. The general prognosis for nasal lymphoma is rather poor, with a mean survival time from diagnosis of approximately two and a half years. Gaal K et al. Sinonasal NK/T-cell lymphomas in the United States.