What is the Cockcroft-Gault equation?
The Cockcroft-Gault formula for estimating creatinine clearance (CrCl) should be used routinely as a simple means to provide a reliable approximation of residual renal function in all patients with CKD. The formulas are as follows: CrCl (male) = ([140-age] × weight in kg)/(serum creatinine × 72)
Is eGFR and creatinine clearance the same?
As an alternative, the estimated Glomerular filtration rate (eGFR) based on serum creatinine is used to assess renal function. Creatinine clearance (CrCl) is also used as an estimate of GFR.
What is 140 in Cockcroft-Gault formula?
The Cockcroft-Gault formula reads: GFR estimate = (140 − age (years) × weight (kg) × constant/serum creatinine(μmol/L)The published constants are 1.23 for males of any age, and 1.05 for females of any age[4].
What is a normal creatinine clearance level?
Normal Results Clearance is often measured as milliliters per minute (mL/min) or milliliters per second (mL/s). Normal values are: Male: 97 to 137 mL/min (1.65 to 2.33 mL/s). Female: 88 to 128 mL/min (1.496 to 2.18 mL/s).
What is normal GFR?
A GFR of 60 or higher is in the normal range. A GFR below 60 may mean kidney disease. A GFR of 15 or lower may mean kidney failure.
What is GFR reading?
A glomerular filtration rate (GFR) is a blood test that checks how well your kidneys are working. Your kidneys have tiny filters called glomeruli. These filters help remove waste and excess fluid from the blood. A GFR test estimates how much blood passes through these filters each minute.
What do you need to know about Cockcroft Gault?
Cockcroft-Gault formula. A calculation used to estimate creatinine clearance based on age, weight, serum creatinine, and gender. Estimated creatinine clearance may be used to adjust dosages of renally excreted drugs.
Is the Cockcroft-Gault formula adjusted for body surface area?
Cockcroft-Gault Formula. The Cockcroft and Gault formula (CG) was developed in 1973 using data from 249 men with creatinine clearance (CCr) from approximately 30 to 130 mL/m2. It is not adjusted for body surface area. CG is no longer recommended for use because it has not been expressed using standardized creatinine values.
When was the Cockcroft-Gault equation first used?
The original Cockcroft-Gault equation, derived in 1976, relied on non-standardized creatinine measurements. With the use of internationally standardized creatinine measurements, the equation significantly overestimates the GFR (10-40%).
How is the Cockcroft Gault formula related to GFR?
We used the Cockcroft-Gault formula to estimate GFR which was derived from estimation of creatinine production based on gender, age, and weight [7].