What class of drugs is tacrolimus?
Tacrolimus is in a class of medications called immunosupressants. It works by decreasing the activity of the immune system to prevent it from attacking the transplanted organ.
What is tacrolimus capsules used for?
Tacrolimus is used with other medications to prevent rejection of a kidney, heart, or liver transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body’s defense system (immune system) to help your body accept the new organ as if it were your own.
Is tacrolimus a macrolide?
Tacrolimus (FK506) is a macrolide immunosuppressant produced by the fungus Streptomyces tsukubaensis. The drug is indicated for liver transplant rejection prophylaxis and is under investigation for use in kidney, cardiac, pancreas, small bowel, and bone marrow transplantation.
What is the indication of tacrolimus?
Tacrolimus ointment is used to treat the symptoms of eczema (atopic dermatitis; a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes) in patients who cannot use other medications for their condition or whose eczema has not responded to another medication.
Can I take amoxicillin with tacrolimus?
Tacrolimus may decrease the excretion rate of Amoxicillin which could result in a higher serum level. Tacrolimus may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Is tacrolimus antifungal?
Tacrolimus had an antifungal effect against approximately 50% of the Malassezia strains, with MICs ranging from 16 to 32 μg/ml.
When is the best time to take tacrolimus?
Take it on an empty stomach in the morning, at least 1 hour before or 2 hours after a meal, at the same time every day. Swallow the tablet whole with liquid (preferably water). Do not crush, chew, or divide it. Do not drink alcohol with the tablet.
What is normal tacrolimus level?
Most individuals display optimal response to tacrolimus with trough whole blood levels of 5.0 to 15.0 ng/mL. Preferred therapeutic ranges may vary by transplant type, protocol, and comedications.
Is tacrolimus a biologic?
Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given….Tacrolimus.
| Clinical data | |
|---|---|
| show IUPAC name | |
| CAS Number | 104987-11-3 |
| PubChem CID | 445643 |
| DrugBank | DB00864 |
Is tacrolimus a Dmard?
mycophenolate mofetil (mmF), azathioprine and tacrolimus are three conventional DmarDs that originate from the field of transplantation medicine, but have been repurposed for the treatment of rheumatic diseases.
Is tacrolimus an antibiotic?
Tacrolimus is a macrolide antibiotic produced by the soil fungus Streptomyces tsukubaensis.
Are there side effects to taking tacrolimus capsules?
Many other drugs affect how much of this medicine (tacrolimus capsules) is in your body. This may raise the chance of organ rejection or raise the chance of side effects. If you take other drugs, check with your doctor to see if you need to have your blood work checked more closely while taking them with this medicine (tacrolimus capsules).
How much tacrolimus is in a Prograf capsule?
Prograf is available for oral administration as capsules (tacrolimus capsules) containing the equivalent of 0.5 mg, 1 mg or 5 mg of anhydrous tacrolimus. Inactive ingredients include lactose, hydroxypropyl methylcellulose, croscarmellose sodium, and magnesium stearate.
Is there additional pediatric use information for tacrolimus?
Additional pediatric use information is approved for Astellas Pharma US, Inc.’s Prograf (Tacrolimus) products. However, due to Astellas Pharma US, Inc.’s marketing exclusivity rights, this drug product is not labeled with that information.
How are tacrolimus capsules used in liver transplants?
Tacrolimus Capsules is indicated for the prophylaxis of organ rejection in patients receiving allogeneic liver transplants. It is recommended that tacrolimus be used concomitantly with adrenal corticosteroids [see Clinical Studies ( 14.2 )] .