For which purpose is desirudin indicated?
Desirudin is used to prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). A DVT can occur after certain types of surgery. Desirudin is for use after hip replacement surgery.
Why desirudin is given sc?
Desirudin is administered subcutaneously for preventing venous thromboembolism postoperatively in patients undergoing elective hip replacement surgery. Dosage is subcutaneous injection 15 mg twice daily.
How do you administer desirudin?
Desirudin is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself. Desirudin is usually given every 12 hours for up to 12 days after your surgery. Follow your doctor’s dosing instructions very carefully.
What is bivalirudin used for?
Bivalirudin is a medication used to manage and treat patients undergoing percutaneous coronary intervention for acute myocardial infarction.
What are the side effects of argatroban?
Common side effects of Argatroban injection include:
- nausea,
- vomiting,
- diarrhea,
- stomach pain,
- fever,
- headache,
- back pain, or.
- minor bleeding or irritation at the injection site.
Does heparin give you a headache?
Tell your doctor right away if you develop any signs of serious bleeding, including unusual pain/swelling/discomfort, prolonged bleeding from cuts or gums, persistent nosebleeds, unusually heavy/prolonged menstrual periods, unusual/easy bruising, dark urine, black stools, severe headache, unusual dizziness.
Is bivalirudin approved for hit?
Bivalirudin is the most recent direct thrombin inhibitor to be introduced to the market, but it is not currently FDA approved for HIT.
Does bivalirudin require routine monitoring?
With the exception of desirudin and dabigatran etexilate, the remaining parenteral DTIs (argatroban, bivalirudin, and lepirudin) require routine laboratory monitoring of their therapeutic effect while balancing the risk of bleeding with that of clinical efficacy.
What kind of drug is argatroban?
Argatroban is a medication used in the management of heparin-induced thrombocytopenia (HIT), which is a rare, life-threatening complication of heparin therapy. It is a direct thrombin inhibitor, a class of anticoagulant drugs.
Does argatroban affect PTT?
Monitoring of argatroban anticogulation An infusion of 2 μg/kg/min argatroban is expected to increase aPTT 1.5-fold, whereas an infusion of 10 μg/kg/min can prolong a PTT up to 3-fold.
Does fondaparinux cause thrombocytopenia?
It seems plausible that anti-PF4/heparin antibodies generated through previous exposure to fondaparinux resulted in a clinical syndrome of HIT. The rapidity of thrombocytopenia with thrombosis suggests an anamnestic response to preformed anti-PF4/heparin antibodies upon exposure to enoxaparin.