Does berberine affect heart rate?

Does berberine affect heart rate?

Berberine, at low concentrations, 2 to 4 μg/mL, increased cardiac contractility and coronary flow with little effect on the heart rate (19). The hypo- tensive action of berberine has been attributed to its ability to enhance the hypotensive effect of acetylcholine (20).

Why does HR increase with infection?

This allows white blood cells and proteins from your blood to move into the damaged tissues to help fight the infection. When your blood vessels expand, signals are sent to your brain to increase your heart rate and pump more blood to the inflamed regions [2].

Can berberine cause shortness of breath?

Standard doses of berberine are generally well tolerated and eventual adverse events are rare and mild. On the contrary, high doses have been associated with arterial hypotension, dyspnea, flu-like symptoms, gastrointestinal discomfort, constipation, and cardiac damage.

What is significant bradycardia?

The hearts of adults at rest usually beat between 60 and 100 times a minute. If you have bradycardia, your heart beats fewer than 60 times a minute. Bradycardia can be a serious problem if the heart rate is very slow and the heart can’t pump enough oxygen-rich blood to the body.

Is berberine safe for long term use?

When taken by mouth: Berberine is possibly safe for most adults. It’s been used safely in doses up to 1.5 grams daily for 6 months. Common side effects include diarrhea, constipation, gas, and upset stomach.

Does berberine raise BP?

Berberine might decrease blood pressure in some people. Taking berberine along with medications used for lowering high blood pressure might cause your blood pressure to go too low. However, it’s not known if this is a big concern. Do not take too much berberine if you are taking medications for high blood pressure.

Is it safe to take berberine long term?