What did the UKPDS show?
The UKPDS demonstrated that any improvement in glycaemic control and blood pressure reduces diabetes-related complications. In trials such as this, patients are selected both by investigators and by themselves.
What is legacy effect in medicine?
The “legacy effect” describes the long-term benefits that may persist for many years after the end of an intervention period, involving different biological processes.
What is legacy effect in diabetes?
The “legacy effect” describes the long-term health benefits that result from intensive (or tight) blood glucose management in diabetes care compared to standard glucose control.
What does legacy effect mean?
In the context of medicine, the ‘legacy effect’ is defined as a phenomenon of continuous beneficial effect of the intensive control on disease outcomes or complications even after a long duration of cessation of the intervention.
What does Ukpds stand for?
Background The UK Prospective Diabetes Study (UKPDS) was a randomised controlled clinical study which looked at the effect of improved blood glucose and blood pressure control on macro- and microvascular complications in Type 2 diabetes.
Does metformin have cardiovascular benefit?
Recent studies have also found that metformin has a positive effect on cardiovascular protection [8,9,10,11,12]. Metformin also lowers risk factors for cardiovascular disease such as blood fats [13,14,15], body weight and blood pressure.
What is an environmental legacy?
Legacy effects are environmental changes resulting from antecedent human disturbances. The disturbance may be a result of changes in land use and land cover, fire regime, water diversions, introductions of chemicals or isotopes, other disruptions in natural systems, or combinations of these changes.
What is metabolic memory?
Metabolic memory is a term used to describe beneficial effects of immediate intensive treatment of hyperglycemia and the observation that they are maintained for many years, regardless of glycemia in the later course of diabetes.
What is environmental legacy?
What are legacy impacts on the landscape?
The strong, lingering effects of historical events on ecosystems are known as landscape legacies. The duration of such impacts can be surprisingly long, particularly for ecosystem properties that are physically af- fected by past events.
When was Ukpds published?
The UKPDS, which published its primary findings in 1998, provided the first evidence that controlling people’s blood sugar reduced their risk for developing micro- and macrovascular complications. “Until the UKPDS reported there was some doubt about that,” says Matthews.
How many patients were enrolled in The UKPDS study?
The recruitment of patients, study protocol, and methods for the UKPDS have been reported previously. 7,8 Approval was obtained from the ethics committees at all 23 clinical centers, and the study conformed to the Declarations of Helsinki guidelines. Briefly, 5102 of 7616 patients who underwent screening were enrolled from 1977 to 1991.
Is the UKPDS effective in reducing microvascular disease?
Although the UKPDS conclusively showed the benefit of improved glycemic control in reducing the risk of microvascular disease, risk reductions for myocardial infarction and death from any cause were observed only with extended post-trial follow-up.
When did The UKPDS intervention trial come to an end?
Post trial monitoring. When the intervention trial finished in September 1997, all surviving UKPDS patients were entered into a ten-year, post-trial monitoring programme. This was completed in December 2007 with the results to be presented at the September 2008 EASD meeting.
Why is the UK Prospective Diabetes Study ( UKPDS ) important?
The United Kingdom Prospective Diabetes Study (UKPDS) was conceived to explore these uncertainties and provide clearer guidelines for the management of type 2 diabetes. Go to: Design of the UKPDS (Figures 1–3) Figure 1 UKPDS–the principal questions. Figure 3 Design of UKPDS.