What can kidney transplant patients take for gout?
Prophylactic and treatment options include allopurinol, colchicine, corticosteroids, and, if absolutely necessary, nonsteroidal antiinflammatory drugs.
Is allopurinol safe for kidney transplant patients?
With appropriate monitoring and dose adjustment, the combined use of allopurinol and azathioprine is safe and effective in renal transplant recipients suffering from recurrent gout, Dr. Borman’s group concluded. They recommended that the azathioprine dose be reduced by 75% prior to the introduction of allopurinol.
Do kidney transplant patients get gout?
Kidney transplant recipients have a higher prevalence of severe uncontrolled gout and higher rates of allopurinol discontinuation. Gout is more severe and difficult to treat in patients with a history of kidney transplantation (KT) than in those without a KT history, a new study suggests.
Why do kidney transplant patients get gout?
Reduced uric acid excretion can occur after kidney transplantation, leading to hyperuricemia and, in some cases, gout [1-4]. This problem is more common among patients treated with calcineurin inhibitors (especially cyclosporine) to prevent graft rejection.
Can kidney transplant patients take colchicine?
Colchicine is widely employed for the treatment of gout in renal transplant patients where NSAIDs are contra-indicated and allopurinol prophylaxis is often avoided due to concomitant azathioprine immunosuppression.
Does tacrolimus cause gout?
Although tacrolimus, a calcineurin-inhibitor with similar nephrotoxic properties to cyclosporine, has been associated with hyperuricemia, there are no reports of gout associated with the use of this drug. The development of gout is dependent on a number of factors.
Can gout be fatal?
Myth: Gout is painful, but it won’t kill you. Truth: Gout can’t kill you directly, but it can cause serious health problems that may eventually kill you, says Robert Keenan, M.D., assistant professor of medicine at Duke University.