Where is interstitium of kidney?
In all parenchymal organs, including the kidney, the interstitium is situated in the space between the basement membranes of the epithelial cells and of the nutritive capillaries (Fig. 1). This compartment is of eminent functional relevance in the healthy and diseased kidney.
What is an interstitium?
The interstitium is a contiguous fluid-filled space existing between a structural barrier, such as a cell wall or the skin, and internal structures, such as organs, including muscles and the circulatory system.
What is renal cortical interstitium?
The renal interstitial compartment, situated between basement membranes of epithelia and vessels, contains two contiguous cellular networks. Fibroblasts are interconnected by junctions and connected to basement membranes of vessels and tubules by focal adhesions. Fibroblasts constitute the “skeleton” of the kidney.
Are interstitial and interstitium the same?
The fluid in the connective tissue spaces is called interstitial fluid. Interstitial fluid is important because it bathes cells, supplying them with essential substances and removing harmful ones. A space containing the fluid is known as an interstitial space. The connected spaces form the interstitium.
What are the functions of the renal interstitium?
Rather, it mediates and in fact modulates almost all exchange among the tubular and vascular elements of the renal parenchyma; along with segmental specialization of the nephron, it underlies the functional zonation of the kidney; it probably influences glomerular filtration through its effects on tubuloglomerular …
What is inner medullary interstitium?
The medullary interstitium is the tissue surrounding the loop of Henle in the medulla. It functions in renal water reabsorption by building up a high hypertonicity, which draws water out of the thin descending limb of the loop of Henle and the collecting duct system.
What is the alveolar interstitium?
The parenchymal or alveolar interstitium provides delicate fibers to support the intralobular air-exchanging portion of the lung. The space between the visceral pleura and the lung parenchyma is termed the peripheral (or subpleural) interstitium and sends strong supporting fibers to the parenchyma.
What is the structure of interstitium?
The interstitium is composed mainly of collagen types I, III, and V, elastin, and glycosaminoglycans (mucopolysaccharides, such as hyaluronate and proteoglycans) which are mechanically entangled and cross-linked to form a gel-like reticulum reminiscent of a brush-pile in terms of its three-dimensional organization ( …
What is renal interstitium made of?
The renal interstitium is made up mainly of a loose matrix of collagens (especially types I and III), pro- teoglycans [9] and fluid in which both resident and nonresident cells are distributed [1, 10].
Where is the medullary interstitium?
loop of Henle
The medullary interstitium is the tissue surrounding the loop of Henle in the medulla. It functions in renal water reabsorption by building up a high hypertonicity, which draws water out of the thin descending limb of the loop of Henle and the collecting duct system.
What is alveolar interstitium?
What is the interstitium of nephron?
The interstitium of the kidney comprises the extravascular intertubular spaces of the renal parenchyma, with their attendant cellular elements and extracellular substances. The interstitium of the kidney is not a simple passive space in which the “true” functional units—nephrons and vessels—are embedded.