Who discovered PSMA?
The story of the prostate-specific membrane antigen (PSMA) began with development of the prostate cancer cell line LNCaP by Horoszewicz et al. (1) in 1983.
What is PSMA therapy?
You may be offered lutetium-177 PSMA therapy (lutetium PSMA), or Prostate-Specific Membrane Antigen therapy if you have advanced prostate cancer. It’s a type of Peptide Receptor Radionuclide Therapy (PRRT). Lutetium PSMA therapy aims to improve your symptoms and reduce the size of your tumours.
What is the function of PSMA?
PSMA is a unique cell surface marker, negatively regulated by androgen and extensively used for imaging of hormone refractory carcinomas and metastatic foci. PSMA is a carboxypeptidase with two important enzymatic functions, namely, folate hydrolase and NAALADase.
Is PSMA same as PSA?
In contrast to other well-known prostate-restricted molecules such as prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP) that are secretory proteins, PSMA is an integral cell-surface membrane protein that is not secreted, thereby making PSMA an ideal target for monoclonal antibody (mAb) therapy.
What does PSMA stand for?
PSMA-PET scans look for areas of the body where the PSMA protein is found, showing the presence of prostate cancer cells. PSMA stands for prostate specific membrane antigen – a protein found on the surface of prostate cancer cells. Gallium-68 refers to the radioactive part of the PET scan.
What is PSMA imaging?
Prostate-specific membrane antigen (PSMA) imaging is a nuclear medicine exam using positron emission tomography (PET) to detect prostate cancer. This scan is investigational and has not yet been approved by the U.S. Food and Drug Administration.
How does PSMA therapy work?
By attaching a radioactive isotope to a ligand that specifically targets cells expressing PSMA, we are able to selectively target prostate cancer cells. The ligand binds to the cell while the radioactive isotope (lutetium-177) delivers a high, localised radiation dose, minimising damage to healthy cells.
Where is PSMA found in the body?
PSMA protein (folate hydrolase), located in the brush border surface of small intestine, enables the generation of folates and subsequent folate uptake. The apparent low levels of PSMA expression in the small intestine and salivary glands are most likely related to these biochemical activities.
Is PSMA a biomarker?
Despite in vitro and in vivo studies have demonstrated PSMA expression in various malignant and benign tumors as promising biomarker, its role in BCa diagnosis and evolution has yet to be confirmed10,14,15.
Is PSMA FDA approved?
FDA approved the first PSMA-targeted PET imaging drug, Ga 68 PSMA-11, on December 1, 2020, for the same prostate cancer imaging indications as piflufolastat F 18.
Are PSMA scans FDA approved?
FDA approved the first PSMA-targeted PET imaging drug, Ga 68 PSMA-11, on December 1, 2020, for the same prostate cancer imaging indications as Pylarify.
What is GA PSMA?
Gallium Ga 68 PSMA-11 Injection is a radioactive diagnostic agent indicated for positron emission tomography (PET) of prostate-specific membrane antigen (PSMA) positive lesions in men with prostate cancer with suspected metastasis who are candidates for initial definitive therapy or with suspected recurrence based on …
Where did the discovery of PSMA come from?
In 1987, Horoszewicz et al. first discovered PSMA, a type II transmembrane glycoprotein with the activities of folate hydrolase and N-acetyl-alpha–linked acidic dipeptidase, on the cell membrane of PCa cell line LNCaP.
Can a PSMA antibody be used to treat prostate cancer?
The use of PSMA as a therapeutic antigenic target for antibodies has recently become more than a hypothetical proposal. Recent studies with an anti-PSMA mAb have used linkages to radionuclides to treat metastatic prostate cancer.
Which is the antibody conjugated to PSMA positive cells?
PSMA antibody-drug conjugate (PSMA ADC) is a fully human immunoglobulin G1 anti-PSMA monoclonal antibody conjugated to monomethylauristatin E, which binds to PSMA-positive cells and induces cytotoxicity.
Where is the Prostate Specific Antigen ( PSMA ) located?
Prostate-specific membrane antigen (PSMA), a transmembrane glycoprotein located on the cell membrane, is specifically and highly expressed in prostate cancer (PCa). Besides, its expression level is related to tumor invasiveness.