Can thalassemia cause developmental delay?
This condition occurs almost exclusively in males. Males with alpha thalassemia X-linked intellectual disability syndrome have intellectual disability and delayed development. Their speech is significantly delayed, and most never speak or sign more than a few words.
Can thalassemia cause disability?
Alpha-thalassemia x-linked intellectual disability (ATRX) syndrome is a genetic condition that causes intellectual disability, muscle weakness ( hypotonia ), short height, a particular facial appearance, genital abnormalities, and possibly other symptoms.
Is alpha thalassemia trait a disability?
Alpha thalassemia/intellectual disability chromosome 16 (ATR-16) syndrome is an extremely rare disorder characterized by intellectual disability, which is milder than in ATR-X syndrome, and alpha thalassemia, which is more severe than in ATR-X syndrome.
What is X Linkedintellectual disability?
X-linked intellectual disability, Siderius type is a condition characterized by mild to moderate intellectual disability that affects only males. Affected boys often have delayed development of motor skills such as walking, and their speech may be delayed.
Can I pass thalassemia to my kids?
Thalassemias are inherited conditions — they’re carried in the genes and passed on from parents to children. People who are carriers of a thalassemia gene show no thalassemia symptoms and might not know they’re carriers. If both parents are carriers, they can pass the disease to their kids.
Is alpha thalassemia a rare disease?
Severe forms of alpha thalassemia (HbH disease and Hb Bart’s hydrops fetalis) have been estimated to occur in approximately 1 in 1,000,000 individuals in the general population in Northern Europe and North America.
Is alpha thalassemia serious?
In addition to anemia and hydrops fetalis, severe cases of alpha thalassemia and hemoglobin H disease can lead to serious complications, especially if untreated. Complications of alpha thalassemia include: Excess iron.
What is alpha thalassemia silent carrier?
Alpha thalassemia silent carrier. One gene is missing or damaged, and the other 3 are normal. Blood tests are usually normal. Your red blood cells may be smaller than normal. Being a silent carrier means you don’t have signs of the disease, but you can pass the damaged gene on to your child.
What gene causes intellectual disability?
Fragile X is the most common known cause of inherited (genetic) intellectual disability.
Is intellectual disability more common in males or females?
Intellectual disability affects about 1% of the population, and of those about 85% have mild intellectual disability. Males are more likely than females to be diagnosed with intellectual disability.