What is thyroid Organification?
Organification is a biochemical process that takes place in thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the oxidation of iodide by the enzyme thyroid peroxidase (TPO).
How is congenital hypothyroidism detected?
Diagnosis of primary hypothyroidism is confirmed by demonstrating decreased levels of serum thyroid hormone (total or free T4) and elevated levels of thyroid-stimulating hormone (TSH). If maternal antibody–mediated hypothyroidism is suspected, maternal and neonatal antithyroid antibodies may confirm the diagnosis.
What does an abnormal thyroid uptake scan mean?
An abnormal thyroid scan may show a thyroid that’s enlarged or out of position, indicating a possible tumor. Abnormal measurements also may show that your thyroid gland collected too much or too little of the radionuclide.
What is the normal 24 hour radioactive iodine uptake?
These are normal results at 6 and 24 hours after swallowing the radioactive iodine: At 6 hours: 3% to 16% At 24 hours: 8% to 25%
Which is a result of elevated thyroid hormone levels?
Hyperthyroidism (overactive thyroid) occurs when your thyroid gland produces too much of the hormone thyroxine. Hyperthyroidism can accelerate your body’s metabolism, causing unintentional weight loss and a rapid or irregular heartbeat.
Is congenital hypothyroidism a birth defect?
When thyroid hormone deficiency is detected at birth it is called “congenital hypothyroidism”. Babies with congenital hypothyroidism are born with an underactive or absent thyroid gland.
Is congenital hypothyroidism treatable?
Congenital hypothyroidism is treated by giving thyroid hormone medication in a pill form called levothyroxine. Many children will require treatment for life. Levothyroxine should be crushed and given once daily, mixed with a small amount of water, formula, or breast milk using a dropper or syringe.
What does a thyroid scan reveal?
The thyroid scan is used to determine the size, shape and position of the thyroid gland. The thyroid uptake is performed to evaluate the function of the gland. A whole-body thyroid scan is typically performed on people who have or had thyroid cancer.
What is a normal thyroid uptake percentage?
The normal values of thyroid uptake of radiotracer are 3 to 16% at 6 hours and 8 to 25% at 24 hours. These values may change according to laboratory standard techniques or patient dietary habits. The thyroid gland can uptake more or less than normal.
What is the difference between I-123 and I-131?
Iodine, in the form of iodide, is made into two radioactive isotopes that are commonly used in patients with thyroid diseases: I-123 (harmless to thyroid cells) and I-131 (destroys thyroid cells. RAI is safe to use in individuals who have had allergic reactions to seafood or X-ray contrast agents.