How does NF kB cause cancer?
Upon NF-κB inhibition, JNK signaling is unleashed leading to excessive oxidative stress and DNA damage (58, 59). This could be one of the mechanisms by which NF-κB acts as a tumor suppressor in both chemically-induced skin cancer and liver cancer.
Does Nfkb inhibit apoptosis?
Recently NF-kB has been shown to have both proapoptotic and antiapoptotic functions. In T cell hybridomas, both T cell activators and glucocorticoids induce apoptosis. Here we show that blockade of NF-kB activity, using a dominant negative IkBa, has opposite effects on these two apoptotic signals.
How does Nfkb cause apoptosis?
In a number of contexts, and particularly in response to cellular stress, stimulation of the NF-kappaB (NF-κB) pathway promotes apoptosis. One mechanism underlying this pro-apoptotic activity is nucleolar sequestration of RelA, which is reported to cause cell death by repressing NF-κB-driven transcription.
Is NF kB a tumor suppressor?
NF-κB as a tumor promoter and tumor suppressor. In recent years, in vitro studies have established strong support for the critical role of NF-κB in cancer. Abnormally high NF-κB activity is a clinical hallmark of chronic inflammation and has been found in many types of cancer cells.
What is NF kB in cancer?
Nuclear factor-κB (NF-κB), a transcription factor that is essential for inflammatory responses, is one of the most important molecules linking chronic inflammation to cancer, and its activity is tightly regulated by several mechanisms.
What does NF Kappab do?
A well-recognized function of NF-κB is regulation of inflammatory responses. In addition to mediating induction of various pro-inflammatory genes in innate immune cells, NF-κB regulates the activation, differentiation and effector function of inflammatory T cells.
Is NF KB inflammatory?
NF-κB is a central mediator of pro-inflammatory gene induction and functions in both innate and adaptive immune cells.
What is NF kB?
NF-κB is a major transcription factor that regulates genes responsible for both the innate and adaptive immune response. Upon activation of either the T- or B-cell receptor, NF-κB becomes activated through distinct signaling components.
What regulates NF kB?