What is the host cell for yellow fever?
Yellow fever virus enters through the bite of a mosquito where it can remain dormant for 6 to 8 days causing massive viremia or quick infection of host cells, including dendritic cells of the lymph nodes and begins the acute stages of disease [2].
What cells are affected by yellow fever?
Yellow fever is characterized by hepatic dysfunction, renal failure, coagulopathy, and shock [5-8]. The midzone of the liver lobule is principally affected, with sparing of cells bordering the central vein and portal tracts [9].
What type of virus is yellow fever virus?
Yellow fever virus is an RNA virus that belongs to the genus Flavivirus. It is related to West Nile, St. Louis encephalitis, and Japanese encephalitis viruses. Yellow fever virus is transmitted to people primarily through the bite of infected Aedes or Haemagogus species mosquitoes.
Who found the real cause of yellow fever?
Walter Reed first discovered that it was transmitted via the bite of a mosquito while studying yellow fever just outside of Havana at the end of the conflict, which was around the turn of the 20th century. Max Theiler developed the first vaccine for the disease in 1937.
Can humans spread yellow fever?
Yellow fever is typically spread to humans from bites by infected mosquitoes. People cannot spread yellow fever among themselves through casual contact, although the infection could possibly be transmitted directly into the blood through contaminated needles.
How does yellow fever affect cells?
What’s to know about yellow fever? Yellow fever is a hemorrhagic condition that can lead to a high fever, bleeding into the skin, and cell death in the liver and kidneys. If enough liver cells die, liver damage occurs, leading to jaundice, a condition in which the skin takes on a yellowish color.
What parts of the body does yellow fever affect?
High fever returns and several body systems are affected, usually the liver and the kidneys. In this phase people are likely to develop jaundice (yellowing of the skin and eyes, hence the name ‘yellow fever’), dark urine and abdominal pain with vomiting. Bleeding can occur from the mouth, nose, eyes or stomach.
Can humans transmit yellow fever?
Yellow fever is an epidemic-prone mosquito-borne vaccine preventable disease that is transmitted to humans by the bites of infected mosquitoes.
How many died of yellow fever?
Yellow fever epidemics caused terror, economic disruption, and some 100,000-150,000 deaths.
Who Solved yellow fever?
In 1951, Max Theiler of the Rockefeller Foundation received the Nobel Prize in Physiology or Medicine for his discovery of an effective vaccine against yellow fever—a discovery first reported in the JEM 70 years ago. This was the first, and so far the only, Nobel Prize given for the development of a virus vaccine.
Does yellow fever still exist today?
The yellow fever virus is found in tropical and subtropical areas of Africa and South America. The virus is spread to people by the bite of an infected mosquito. Yellow fever is a very rare cause of illness in U.S. travelers.