What is a clear cell Acanthoma?
Clear cell acanthoma is an uncommon type of benign epithelial tumor. Typically, it is a solitary lesion found on the lower limbs. It presents as a nodule or small plaque with slow and well-defined growth.
How common is clear cell Acanthoma?
[1] It is a rare, benign tumor of unknown etiology. Although most commonly located on the lower extremities, clear cell acanthomas can also appear on the trunk, forearm, face, inguinal area, and few cases of nipple and areola lesions have been reported.
What does Acanthoma mean?
An acanthoma is a small, reddish bump that usually develops on the skin of an older adult. There are several types of acanthoma, including “acantholytic”, “epidermolytic”, “clear cell “, and “melanoacanthoma”.
What are symptoms of Acanthoma?
Symptoms and Clinical Presentation LCA can be dome in shape or nodular. The color or LCA varies from pinkish brown but typically blood red and shiny appearance. The wafer-like crusty, scale may be found around the edges of the lesion with a moist nikolsky’s sign appearance when the scales are removed.
Why is it called clear cell carcinoma?
Clear cell renal cell carcinoma is also called conventional renal cell carcinoma. Clear cell renal cell carcinoma is named after how the tumor looks under the microscope. The cells in the tumor look clear, like bubbles.
What are symptoms of acanthoma?
What is the survival rate of clear cell carcinoma?
The 5-year survival rate for patients with ccRCC is 50-69%. When ccRCC is already large or has spread to other parts of the body, treatment is more difficult and the 5-year survival rate is about 10%.
How fast does clear cell carcinoma grow?
Clear cell carcinoma (0.86 cm/year) tended to grow faster than papillary cell carcinoma (0.28 cm/year) (P = 0.066).
Is clear cell carcinoma hereditary?
When the FLCN gene is mutated, uncontrolled cell growth may result that leads to cancer. Mutated copies of the FLCN gene are passed from parents to children. The syndrome caused by these mutations is inherited in an autosomal dominant fashion.
Is clear cell carcinoma curable?
Patients with clear cell renal cell carcinoma (CCRCC) tend to have a worse prognosis than patients with other histologic subtypes of RCC, with 5-year disease-specific survival rates of 50-69%, compared with 67-87% for papillary RCC and 78-87% for chRCC.
What is the dermoscopic feature of clear cell acanthoma?
Even though clear cell acanthoma has a non-specific clinical appearance, it has a relatively specific and easy to recognize dermoscopic feature called ‘ string of pearls ‘, referring to dotted vessels that are arranged in a linear of serpiginous pattern .
How big is a clear cell acanthoma tumor?
Clear cell acanthoma is a rarely diagnosed tumor with variable clinical morphology that is usually only recognized by its histopathological features. The primary lesion is a red papule a few millimeters in diameter that often occurs as a single lesion on the lower extremities. In dermoscopy, resembl …
What kind of vessels are found in clear cell acanthomas?
In dermoscopy, resemblance of the vessels to a string of pearls is a largely specific finding of clear cell acanthoma. In contrast to the initially uncharacteristic clinical findings, histopathology of clear cell acanthomas is characterized by a typical compact, well-demarcated acanthosis consisting of pale-staining, PAS-reactive keratinocytes.