What is pathogenesis of systemic lupus erythematosus?
Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE.
What is the pathology of lupus?
Lupus results from a breakdown of the normal disease-fighting function of the immune system. Instead of producing antibodies that attack infectious organisms, the body produces antibodies—called autoantibodies—that react with components of the body’s own tissues.
What is lupus PDF?
Lupus is an autoimmune disease. This means that your immune system attacks healthy cells and tissues by mistake. This can damage many parts of the body, including the joints, skin, kidneys, heart, lungs, blood vessels, and brain. Yes. Systemic lupus erythematosus (SLE) is the most common and most serious type.
What are the factors that affect lupus erythematosus formation?
There is strong epidemiologic evidence linking environmental factors, including current cigarette smoking(12–14), crystalline silica exposure (15–17), alcohol consumption (decreased risk) (18, 19), oral contraceptives and postmenopausal hormones with the development of SLE(20–23).
Which of the following cutaneous manifestations of SLE are included in lupus diagnostic criteria?
Cutaneous manifestations of SLE include malar rash, photosensitivity, and discoid lupus.
What happens in SLE?
SLE is one of a large group of conditions called autoimmune disorders that occur when the immune system attacks the body’s own tissues and organs. SLE may first appear as extreme tiredness (fatigue), a vague feeling of discomfort or illness (malaise), fever, loss of appetite, and weight loss.
What is the age group for lupus?
Age. Although lupus affects people of all ages, it’s most often diagnosed between the ages of 15 and 45. Race. Lupus is more common in African Americans, Hispanics and Asian Americans.
Why the females are more prone to SLE?
Conclusions: The increased frequency of SLE among women may be attributed to differences in the metabolism of sex hormones and/or GnRH. Though less common in men, when it does occur SLE tends to run a more severe course-an important consideration in the diagnosis and follow-up of male patients with SLE.
What is the difference between pathogenesis and pathology?
Pathology is that field of science and medicine concerned with the study of diseases, specifically their initial causes (etiologies), their step-wise progressions (pathogenesis), and their effects on normal structure and function.
Who are the authors of systemic lupus pathogenesis?
George Bertsias, Ricard Cervera, Dimitrios T Boumpas A previous version was coauthored by Ricard Cervera, Gerard Espinosa and David D’Cruz Systemic Lupus Erythematosus: Pathogenesis 20 and Clinical Features 1 Introduction
Which is a genetic risk factor for SLE?
For instance, STAT4, a genetic risk factor for rheumatoid arthritis and SLE, is associated with severe SLE. One of the key components of these pathways is TNFAIP3, which has been implicated in at least six autoimmune disorders]
What kind of Aetiology does SLE have?
The exact aetiology of SLE is unknown. SLE shows a strong familial aggregation, with a much higher frequencyamongfirstdegreerelativesofpatients. Moreover, in extended families, SLE may coexist with other organ specific autoimmune diseases such as haemolytic anaemia, immune thrombo- cytopenic purpura, and thyroiditis.
Which is an example of an environmental trigger for SLE?
Candidate environmental triggers of SLE include ultraviolet light, demethylating drugs, and infectious or endogenous viruses or viral-like elements. Sunlight is the most obvious environmental factor that may exacerbate SLE.