What means down regulation?
Downregulation: An decrease in the number of receptors on the surface of target cells, making the cells less sensitive to a hormone or another agent. For example, insulin receptors may be downregulated in type 2 diabetes.
Is down regulate one word?
n. a decrease in the number of receptor molecules in a given area.
What is an example of down regulation?
An example of downregulation is the cellular decrease in the expression of a specific receptor in response to its increased activation by a molecule, such as a hormone or neurotransmitter, which reduces the cell’s sensitivity to the molecule. This is an example of a locally acting (negative feedback) mechanism.
What is down regulation in psychology?
Down regulation is the process by which a cell decreases the number of receptors to a given hormone or neurotransmitter to reduce its sensitivity to this molecule. This is a locally acting negative feedback mechanism. An increase of receptors is called up regulation.
Is down regulation good?
In summary, the ability to go within and really settle oneself is developed during infancy and childhood. This capacity to downregulate stress states is important in maintaining health, relationships, and happiness.
What is down regulation receptors?
Receptor downregulation is characterized by a decrease in total receptor number in the cell due to endocytosis and subsequent degradation of the receptors caused by long-term exposure to agonists (see Fig. 5-7). Downregulation is also an important cellular mechanism during long-term administration of therapeutic drugs.
What is down Reg IVF?
Downregulation is usually the first stage of a high stimulation IVF treatment protocol – it is the name given to the process of using medication to shut down your natural menstrual cycle, in effect causing an artificial menopause.
What is the difference between down-regulation and upregulation?
Downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external variable. An increase of a cellular component is called upregulation.
What is down-regulation in IVF?
What causes down regulation to occur?
Mechanism. The process of downregulation occurs when there are elevated levels of the hormone insulin in the blood. When insulin binds to its receptors on the surface of a cell, the hormone receptor complex undergoes endocytosis and is subsequently attacked by intracellular lysosomal enzymes.
What does down regulated mean?
Down-regulation is a term that scientists use to describe the process of reducing or suppressing the body’s response to specific stimuli. When used with regard to in vitro fertilization (IVF), down-regulation essentially “turns off” the ovaries to better control ovulation and egg maturation during treatment.
What is up and down regulation?
Down regulation is the process by which a cell decreases the number of receptors to a given hormone or neurotransmitter to reduce its sensitivity to this molecule. This is a locally acting negative feedback mechanism. An increase of receptors is called up regulation.
What does up regulation mean?
Medical Definition of upregulation. : the process of increasing the response to a stimulus specifically : increase in a cellular response to a molecular stimulus due to increase in the number of receptors on the cell surface.