What is Margination in biology?
Medical Definition of margination 1 : the act or process of forming a margin specifically : the adhesion of white blood cells to the walls of damaged blood vessels.
What is Margination in leukocytes?
[mar″jĭ-na´shun] accumulation and adhesion of leukocytes to the epithelial cells of blood vessel walls at the site of injury in the early stages of inflammation.
What is the Margination?
Margination is defined as the movement of particles in flow toward the walls of a channel. The margination of particles in blood has applications in microfluidic devices for the removal of pathogens and separation of cells (1–4).
What causes Margination?
When the gap size between the cell surface and the wall becomes larger than the thickness of RBCs, margination is caused by overtaken or overtaking events.
What causes Margination of neutrophils?
Flow of blood in a microvessel. Central flow of red cells, promoted by red cell aggregation, assists margination of neutrophils. Increasing hematocrit and aggregation increase the blunting of the flow velocity profile (plug flow) and increase the wall shear rate.
What causes leukocyte adhesion to endothelial cells?
Lectin-like adhesion glycoproteins, called the selectins, mediate leukocyte rolling, while the firm adhesion and subsequent transendothelial migration of leukocytes are mediated by the interaction of integrins (CD11/CD18, VLA-4) on leukocytes with immunoglobulin-like adhesion molecules on ECs (e.g., ICAM-1, VCAM-1).
What is the main cause of the Margination seen by leukocytes?
The passing motion of RBCs is a result of the velocity difference between RBCs flowing near the center of the vessel and leukocytes flowing near the wall. We show that leukocyte margination occurs due to the passing motion of RBCs for a wide range of channel diameters.
Where can I find the definition of margination?
Also found in: Dictionary, Encyclopedia, Wikipedia. margination [mar″jĭ-na´shun] accumulation and adhesion of leukocytes to the epithelial cells of blood vessel walls at the site of injury in the early stages of inflammation.
When does margination occur in the blood stream?
A phenomenon that occurs during the relatively early phases of inflammation; as a result of dilation of capillaries and slowing of the bloodstream, leukocytes tend to occupy the periphery of the cross-sectional lumen and adhere to the endothelial cells that line the vessels. margination.
How is a marginated cell captured by the vascular wall?
Multistep cell adhesion in microcirculatory blood flow. A cell flowing near the vascular wall (marginated cell) is captured by ligand-receptor bonds of adhesion proteins. While the cell exhibits rolling motion on the wall under weak bonds, it firmly adheres to the wall under strong bonds.
Is there extravasation or margination of white blood cells?
There is margination and extravasation of white blood cells into the tissue and expression of inflammatory mediators and growth factors. Other empirical investigations have confirmed the margination factor (margination theory) as a determinant of entrepreneurship.