What is the function of merlin protein?
Merlin helps regulate several key signaling pathways that are important for controlling cell shape, cell growth, and the attachment of cells to one another (cell adhesion). This protein functions as a tumor suppressor, preventing cells from growing and dividing too fast or in an uncontrolled way.
What type of protein is Neurofibromin?
Neurofibromin is a GTPase-activating protein of Ras (Ras-GAP). It downregulates the Ras signaling pathway by promoting the hydrolysis of the active form of Ras (GTP-bound Ras) to an inactive form of Ras (GDP-bound Ras) by increasing the intrinsic GTPase activity of Ras [20,21,22].
What gene is responsible for neurofibromatosis?
NF1 is caused by changes (mutations) in a gene called NF1, which is found on chromosome 17. This gene regulates the production of a protein known as neurofibromin, which is thought to function as a tumor suppressor.
Where is Neurofibromin found?
Neurofibromin 1 (NF1) is a gene in humans that is located on chromosome 17.
What is Merlin biology?
Merlin (Moesin-ezrin-radixin-like protein, also known as schwannomin) is a tumor suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function mutations or deletions in NF2 cause neurofibromatosis type 2 (NF2), a multiple tumor forming disease of the nervous system.
Is Merlin a tumor suppressor?
Merlin functions as a tumor suppressor through impacting mechanisms related to proliferation, apoptosis, survival, motility, adhesion, and invasion. Several studies have summarized the tumor intrinsic mutations in Merlin.
What are RASopathies?
RASopathies are a group of genetic conditions. They’re called RASopathies (raz-OP-uh-thees) because they’re caused by problems in the RAS pathway, which is one way cells in the body communicate. The individual RASopathies are rare, but as a group: They’re among the most common genetic conditions.
What does NF1 gene stand for?
Neurofibromatosis type 1 (NF1) is a genetic condition that causes tumours to grow along your nerves. The tumours are usually non-cancerous (benign) but may cause a range of symptoms. Neurofibromatosis type 2 (NF2) is much less common than NF1.
How does neurofibromatosis affect DNA?
NF is considered an autosomal dominant disorder because the gene is located on one of the 22 chromosome pairs, called autosomes. The gene for NF1 is located on chromosome 17. The gene for NF2 is located on chromosome 22. Children have a 50 percent chance of inheriting the genes that cause NF if the parent has NF.
What is fn1 disease?
When was Merlin Gene born?
11 Oct 1933
Born in Commerce, Hunt, Texas, USA on 11 Oct 1933 to Chester Merlin SPARKS and FAYE LORENE “Lorene” ROUNDTREE. Merlin Gene Sparks married Dorothy Ann Durham and had 1 child.
How rare is NF2?
NF2 is a rare disorder that affects males and females in equal numbers. All races and ethnic groups are equally affected by this disorder. The estimated incidence of NF2 is 1 in 33,000 people worldwide. The symptoms of this disease typically become apparent during puberty or early adulthood.