Can people with mitochondrial disease have kids?
This separation of mitochondrial and cellular DNA means that if a child’s father has mitochondrial disease due to a gene contained in the mitochondria, it is very unlikely his children will inherit the disease.
How serious is mitochondrial disease?
Mitochondrial disease can cause a vast array of health concerns, including fatigue, weakness, metabolic strokes, seizures, cardiomyopathy, arrhythmias, developmental or cognitive disabilities, diabetes mellitus, impairment of hearing, vision, growth, liver, gastrointestinal, or kidney function, and more.
Can mitochondrial disease go away?
There are no cures for mitochondrial diseases, but treatment can help reduce symptoms or slow the decline in health. Treatment varies from patient to patient and depends on the specific mitochondrial disease diagnosed and its severity.
What is the life expectancy of someone with mitochondrial disease?
A small study in children with mitochondrial disease examined the patient records of 221 children with mitochondrial disease. Of these, 14% died three to nine years after diagnosis. Five patients lived less than three years, and three patients lived longer than nine years.
Does mitochondrial disease cause weight gain?
Differential increases in mitochondrial oxidant production under conditions of chronic positive energy balance could be a major contributory factor to individual susceptibility to weight gain and obesity.
What are three of the most common symptoms of mitochondrial disease?
The main symptoms of mitochondrial myopathy are muscle fatigue, weakness, and exercise intolerance. The severity of any of these symptoms varies greatly from one person to the next, even in the same family. In some individuals, weakness is most prominent in muscles that control movements of the eyes and eyelids.
What vitamins help mitochondria?
B vitamins and lipoic acid are essential in the tricarboxylic acid cycle, while selenium, α-tocopherol, Coenzyme Q10, caffeine, and melatonin are suggested to boost the electron transfer system function. Carnitine is essential for fatty acid beta-oxidation. Selenium is involved in mitochondrial biogenesis.
Can a mitochondrial genetic disorder cause health problems?
This can lead to the variety of health problems associated with mitochondrial genetic disorders. [1] [2] Mitochondrial genetic disorder can be inherited in a variety of manners depending on the type of condition and the location of the disease-causing change ( mutation ).
Can a de novo mutation cause a mitochondrial disorder?
In some cases, the condition results from a new (de novo) mutation in a mitochondrial gene and occurs in a person with no history of the condition in the family. Mitochondrial genetic disorders caused by mutations in nuclear DNA may follow an autosomal dominant, autosomal recessive, or X-linked pattern of inheritance.
What is the treatment for mitochondrial genetic disorders?
Treatment for mitochondrial genetic disorders varies significantly based on the specific type of condition and the signs and symptoms present in each person. The primary aim of treatment is to alleviate symptoms and slow the progression of the condition.
Can a mitochondrial disease be a multisystem disorder?
Adult-onset mitochondrial disease is typically a progressive multisystem disorder. Even in patients presenting with symptoms mainly in one organ system (such as myopathy), there is often evidence of multisystem involvement upon physical examination and laboratory evaluation.