What malignancy is associated with dermatomyositis?
The most common cancers described in cancer associated dermatomyositis (CADM) are: breast cancer, lung, ovary, stomach, intestine, nasal cavity, throat, pancreatic, bladder and Hodgkin’s lymphoma [1–3].
Is dermatomyositis a form of cancer?
Cancer. Dermatomyositis in adults has been linked to an increased likelihood of developing cancer, particularly ovarian cancer in women. Risk of cancer appears to level off three years or so after a diagnosis of dermatomyositis.
What percentage of adult patient with dermatomyositis have an associated malignancy?
Since then, numerous studies have shown the high cancer incidence among patients with idiopathic inflammatory myopathy, especially DM. DM with coexistent malignancy ranges from 6% to 60% of all the DM cases. Five-year survival of adult DM patients is 60% to 90%, and malignancy is the primary cause of death.
Why does dermatomyositis cause cancer?
In these patients, it is believed that the malignancy activates the immune system, which stimulates the development of the autoimmune disease. Cancer-associated myositis occurs most frequently for patients with dermatomyositis. (It has been estimated that as much as 20-30% of DM patients will develop cancer.)
How serious is dermatomyositis?
Dermatomyositis and polymyositis are serious diseases with a disease‐related mortality of at least 10%. In the long term, myositis has a major effect on perceived disability and quality of life, despite the regained muscle strength.
What is necrotizing myopathy?
Definition. Necrotizing autoimmune myopathy (NAM) is a rare form of idiopathic inflammatory myopathy characterized clinically by acute or subacute proximal muscle weakness, and histopathologically by myocyte necrosis and regeneration without significant inflammation.
What organs does dermatomyositis affect?
Dermatomyositis mostly affects the muscles of the hips and thighs, the upper arms, the top part of the back, the shoulder area and the neck.
What is the death rate of dermatomyositis?
Previous studies reported that the connective tissue disease PM/DM has a poor prognosis and high I-HMR. The reported 10-year survival rate ranged between 53% and 91% [4, 9–12]. A very recent population-based study from America reported a hospital mortality of 4.5% [2].