What is a GAVE in the stomach?
GAVE (Gastric Antral Vascular Ectasia), also known as “Watermelon Stomach”, is a condition in which the blood vessels in the lining of the stomach become fragile and become prone to rupture and bleeding.
What is severe GAVE?
Abstract. Gastric antral vascular ectasia (GAVE) is an uncommon but often severe cause of upper gastrointestinal (GI) bleeding, responsible of about 4% of non-variceal upper GI haemorrhage. The diagnosis is mainly based on endoscopic pattern and, for uncertain cases, on histology.
How is GAVE diagnosed?
GAVE is usually diagnosed definitively by means of an endoscopic biopsy. The tell-tale watermelon stripes show up during the endoscopy. Surgical exploration of the abdomen may be needed to diagnose some cases, especially if the liver or other organs are involved.
How do you get GAVE?
While there is no known direct cause of GAVE, the condition is most common in those who have suffered from certain chronic conditions such as cirrhosis (poor liver function, or scarring of the liver), systemic sclerosis, CREST syndrome, atrophic gastritis and autoimmune disease.
Is gave serious?
GAVE is a serious complication of many conditions; available treatment modalities only address active bleeding. We used to think GAVE was a rare manifestation of SSc, but it was simply underdetected.
How serious is Gave disease?
Although GAVE syndrome is a rare medical condition, it is a relevant possibility in older patients with severe acute or chronic gastrointestinal blood loss, because it accounts for up to 4% of nonvariceal upper gastrointestinal blood loss.
How serious is GAVE disease?
Is GAVE disease life threatening?
GAVE is a serious complication of many conditions; available treatment modalities only address active bleeding.
Is there a cure for GAVE?
Overall, medical treatment does not alter the endoscopic/histologic figures of GAVE and has no definite role in the cure of GAVE-related bleeding. Small case-series reports have shown variable improvement of gastrointestinal blood loss but often patients drop out because of medication side-effects.
How do you treat GAVE Disease?
The current standard of care for management of GAVE involves treatment of acute episodes of bleeding with endoscopic procedures and blood transfusions. However, re-bleeding often occurs, requiring repeated treatments.
Is gastric antral vascular ectasia bad?
Gastric antral vascular ectasia (GAVE) is a rare but an important cause of upper gastrointestinal bleeding (UGIB) and commonly presents as occult bleeding that manifests as iron deficiency anemia (IDA). GAVE is commonly associated with chronic illnesses, most frequently liver cirrhosis and connective tissue diseases.
Is GAVE serious?
Where is the antral mucosa located in the stomach?
Antral mucosa is found in the antrum, cardia and pylorus of the stomach, these are the border regions of the stomach. It is made up of loosely packed glands which occupy 1/2 of the mucosal thickness. Here’s a section of the gastric antral mucosa highlighting the foveolae (a) and glands (b).
Which is the best website for stomach histology?
Histology. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachnormalhistology.html. Accessed August 30th, 2021. A review of the normal constituents of the gastric wall, with a focus on the gastric mucosa, its compartments, its cell types and their cellular products
When was gastric antral vascular ectasia first discovered?
Gastric antral vascular ectasia (GAVE) is an uncommon but often severe cause of upper gastrointestinal (GI) bleeding, responsible of about 4% of non-variceal upper GI hemorrhage[1]. This disease was first described in 1953 by Ryder et al[2], but deeply investigated only 25 years later, in 1978, by Van Vliet et al[3].
How does the gastric antrum look at endoscopic ultrasound?
At the endoscopic ultrasound (EUS), the gastric antrum appears hyperthrophic with a spongy appearance of the mucosa and submucosa and a well-preserved muscularis propria[11,12].