How do you give a sodium valproate injection?
Sodium valproate injection may be given by direct slow intravenous injection or by infusion using a separate intravenous line in normal saline, dextrose 5%, or dextrose saline. Dosage requirements vary according to age and body weight. Each vial of sodium valproate injection is for single dose injection only.
What are the main side effects of sodium valproate?
Common side effects
- stomach pain, feeling or being sick.
- diarrhoea.
- dry or sore mouth, or swollen gums.
- shakes (tremors) in a part of your body, or unusual eye movements.
- feeling tired or sleepy.
- headache.
- weight gain.
- thinning hair, or changes to the colour or texture of your hair.
What is Valproic acid side effects?
Valproic acid may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- drowsiness.
- dizziness.
- headache.
- diarrhea.
- constipation.
- changes in appetite.
- weight changes.
- back pain.
How do you administer IV valproic acid?
Administer over 60 minutes. The recommended infusion rate is generally 20 mg/minute. Faster infusion rates of valproate sodium (Depacon) have been studied in a separate clinical safety trial; 112 patients with epilepsy were given infusions of up to 15 mg/kg IV over 5 to 10 minutes (1.5 to 3 mg/kg/minute).
Can sodium valproate be given IM?
Despite tissue damage sodium valproate was well absorbed intramuscularly. The intravenous injection of valproate at high concentrations, large doses and fast infusion rates produced no evidence of cardiotoxicity and levels of 180 micrograms/ml.
What happens if Depakote levels are too high?
Unusual weight gain or loss. Tremors. Blurred or double vision, uncontrolled eye movements. Mood swings.
What are the benefits of valproic acid?
Valproic acid is used to treat bipolar disorder. It’s occasionally used to prevent migraine and can also be used to treat epilepsy. This medicine is only available on prescription.
Can valproic acid be given IV push?
Conclusions: Rapid administration of undiluted valproate is safe and well tolerated at infusion rate up to 10 mg/kg/min and doses of up to 30 mg/kg.
What is valproic acid used for?
Are there any side effects to taking valproate sodium?
Valproate Sodium Vial Side Effects by Likelihood and Severity. COMMON side effects. If experienced, these tend to have a Severe expression. Accidental Injury. Decreased Blood Platelets. Fluid Retention In The Legs, Feet, Arms Or Hands. Involuntary Eye Movement. Trouble Breathing.
How much valproate is in a 5 ml injection?
Valproate Sodium Injection, USP is available in 5 mL single dose vials for intravenous injection. Each mL contains valproate sodium equivalent to 100 mg valproic acid, edetate disodium 0.40 mg, and water for injection to volume. The pH is adjusted to 7.6 with sodium hydroxide and/or hydrochloric acid.
When to switch to oral valproate sodium injection?
Valproate Sodium Injection is for intravenous use only. Use of Valproate Sodium Injection for periods of more than 14 days has not been studied. Patients should be switched to oral valproate products as soon as it is clinically feasible.
What is the molecular structure of valproate sodium?
Valproate sodium has the following structure: CH C O O CH2 CH2CH2 CH2 CH3 CH3 Na Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorless, crystalline, deliquescent powder. DEPACON solution is available in 5 mL single-dose vials for intravenous injection.