How is the articular cartilage damaged in rheumatoid arthritis?
Mediators of cartilage damage in RA Cartilage is largely considered a target tissue in RA, which becomes damaged as a result of the inflamed and hyperplastic synovial membrane, which is itself caused by the manifestation of systemic autoimmunity in articular joints.
What is the typical joint involvement with rheumatoid arthritis group of answer choices?
RA is characterized by a typical pattern and distribution of synovial joint involvement. Disorganization of the joint leads to deformities and loss of function. In the hands, the metacarpophalangeal (MCP), proximal interphalangeal (PIP), and thumb interphalangeal (IP) joints are most frequently involved.
What limits joint movement in osteoarthritis?
OA starts with the breakdown of cartilage in the joint. As the cartilage wears down, the bone ends may thicken and form bony growths. These growths are called bone spurs. Bone spurs can limit joint movement.
Which of the following is characteristic of osteoarthritis?
Joint aching and soreness, especially with movement. Pain after overuse or after long periods of inactivity. Stiffness after periods of rest. Bony enlargements in the middle and end joints of the fingers (which may or may not be painful)
What causes cartilage damage in rheumatoid arthritis?
In rheumatoid arthritis, the body’s immune system attacks the lining of the joint capsule, a tough membrane that encloses all the joint parts. This lining (synovial membrane) becomes inflamed and swollen. The disease process can eventually destroy cartilage and bone within the joint.
What causes cartilage destruction in rheumatoid arthritis?
Cartilage destruction in rheumatoid arthritis was characterized by a disturbed homeostasis of chondrocyte function that leads to an enhanced cartilage catabolism involving extracellular matrix degradation via matrix metalloproteinases and suppressed extracellular matrix synthesis, induction of catabolic cytokines/ …
What joints are affected by rheumatoid arthritis?
RA commonly affects joints in the hands, wrists, and knees. In a joint with RA, the lining of the joint becomes inflamed, causing damage to joint tissue. This tissue damage can cause long-lasting or chronic pain, unsteadiness (lack of balance), and deformity (misshapenness).
How does rheumatoid arthritis differ from osteoarthritis?
The main difference between osteoarthritis and rheumatoid arthritis is the cause behind the joint symptoms. Osteoarthritis is caused by mechanical wear and tear on joints. Rheumatoid arthritis is an autoimmune disease in which the body’s own immune system attacks the body’s joints.
How does arthritis limit movement at a joint?
In some people, the cartilage thins as the joints are used. This is the start of osteoarthritis. Over time, the cartilage wears away and the bones may rub against each other. The rubbing causes pain, swelling, and decreased motion of the joint.
What is the difference between rheumatoid arthritis and osteoarthritis?
Is rheumatoid arthritis systemic?
Rheumatoid arthritis primarily affects the joints but can also affect the whole body, causing what are called systemic symptoms. These systemic symptoms occur especially in people who have severe disease.