What are the recommendations when treating high triglycerides?
Treatment of very high triglyceride levels (i.e., 500 mg per dL [5.65 mmol per L] or higher) is aimed at reducing the risk of acute pancreatitis. Statins, fibrates, niacin, and fish oil (alone or in various combinations) are effective when pharmacotherapy is indicated.
What is the first line treatment for hypertriglyceridemia?
Fibrates are the first-line treatment in patients with hypertriglyceridemia who are at risk of pancreatitis. Fibrates, niacin, and n-3 fatty acids, alone or in combination, should be considered in patients with moderate to severe hypertriglyceridemia.
How do you evaluate hypertriglyceridemia?
The Task Force recommends that the diagnosis of hypertriglyceridemia be based on fasting levels, that mild and moderate hypertriglyceridemia (triglycerides of 150–999 mg/dl) be diagnosed to aid in the evaluation of cardiovascular risk, and that severe and very severe hypertriglyceridemia (triglycerides of > 1000 mg/dl) …
Which medicine is best to reduce triglycerides?
Which Medicines Can Lower Triglycerides?
- Fibrates (Fibricor, Lopid, and Tricor)
- Nicotinic acid (Niaspan)
- High doses of omega-3s are needed to lower triglycerides and should be taken only under a doctor’s care. Epanova, Lovaza, and Vascepa are prescription forms of omega-3s.
Which is better fenofibrate vs gemfibrozil?
Conclusions: Compared with gemfibrozil, fenofibrate produced significantly greater reductions in total cholesterol, LDL, and triglycerides and significantly greater increases in HDL. These changes were evident in patients receiving and not receiving concomitant statin therapy.
When do you start statin guidelines?
This guideline states “In adults 40 to 75 years of age without diabetes mellitus and with LDL-C levels ≥70 mg/dL (≥1.8mmol/L), at a 10-year atherosclerotic cardiovascular disease risk of ≥7.5 percent, start a moderate-intensity statin if a discussion of treatment options favors statin therapy.”
How do you test for familial hypertriglyceridemia?
Exams and Tests If you have a family history of this condition, you should have blood tests to check very low density lipoprotein (VLDL) and triglyceride levels. Blood tests most often show a mild to moderate increase in triglycerides (about 200 to 500 mg/dL). A coronary risk profile may also be done.
How quickly can you reduce triglycerides?
The sooner you can lower your “bad” cholesterol levels, the sooner you can lower your risk for plaques to form. You can also lower your cholesterol through lifestyle and diet changes alone, but it may take three to six months to see results.
Can you take gemfibrozil and fenofibrate together?
Taking the fenofibrate 1 hour before or 4-6 hours after the bile acid sequestrant may prevent this interaction. Taking the gemfibrozil 2 hours before or after the bile acid sequestrant may prevent this interaction. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it.
What is the best medicine for high triglycerides?
One of the medications is gemfibrozil which is excellent for treating triglycerides but has no affect on other problems such as cholesterol. Another medication is fenofibrate which is very effective in lowering high triglycerides.
What are the guidelines for triglycerides?
The recommended level of triglyceride is 100 mg/dL. Levels between 150 and 199 mg/dL can pose some health issues, while levels 200 to 499 pose a higher risk, and maximum risk is observed at levels greater than 500 mg/dL.
Can hypertriglyceridemia lead to pancreatitis?
Mild to moderate hypertriglyceridemia is associated with an increased risk of premature cardiovascular disease (CVD), while severe hypertriglyceridemia can lead to pancreatitis and other features of the chylomicronemia syndrome, as well as an increased risk of premature cardiovascular disease.
How does hypertriglyceridemia cause pancreatitis?
The exact mechanism of how hypertriglyceridemia causes pancreatitis is unknown 3. One theory is that hyperviscosity of blood in the pancreatic capillaries caused by hypertriglyceridemia causes ischemia and injury to the pancreas 3.