What is the latest treatment for pulmonary hypertension?
Riociguat is the first approved medication from the novel class of soluble guanylate cyclase (sGC) stimulators and the only agent approved for treating both chronic thromboembolic hypertension (CTEPH) and pulmonary arterial hypertension (PAH).
Does spironolactone help with pulmonary hypertension?
Lung blood vessel function can be harmed by progressive injuries, such as inflammation, leading to worsening of the disease. A drug called spironolactone has been known to improve blood vessel function and reduce inflammation. Some people with PAH take spironolactone to help treat fluid retention.
What is Sotatercept?
A soluble fusion protein composed of the extracellular domain of the activin receptor type IIA (ActRIIA) linked to the Fc portion of human IgG1 with anabolic bone activity.
Do steroids help pulmonary hypertension?
Over the last several years we have utilized steroids in patients with severe pulmonary hypertension as part of a treatment regimen. These basic science studies possibly identifies a biochemical etiology for the development of disease and may also be impacted by the administration of steroids.
Is spironolactone used in pulmonary edema?
Body weight decreased and the incidence of both pitting and pulmonary oedema was reduced during spironolactone treatment. Plasma sodium level was consistently reduced and plasma potassium increased to accepted normal levels. Seventy-nine patients remained free of side-effects throughout the treatment period.
How is Sotatercept administered?
Sotatercept was administered at dose level 0.1, 0.3, or 1 mg/kg every 28 days subcutaneously for up to four doses. Sotatercept was generally safe and well tolerated, and elicited clinically significant, dose-dependent increases in hemoglobin, hematocrit, and red blood cell counts that persisted for up to 4 months.