How is pemetrexed administered?
Pemetrexed injection comes as a solution (liquid) to be injected into a vein over 10 minutes. Pemetrexed injection is administered by a doctor or nurse in a medical office or infusion center. It is usually given once every 21 days.
How is ALIMTA given?
ALIMTA, KEYTRUDA, and a platinum chemotherapy are given through an intravenous (IV) infusion. Each type of medicine will take a different amount of time. After 4 cycles of treatment, you will stop receiving platinum chemotherapy, which may make visits shorter in length.
When is Pemetrexed used?
Pemetrexed is used to treat certain types of cancer (such as lung cancer, mesothelioma). It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.
Is pemetrexed well tolerated?
Pemetrexed is a key anticancer agent for treatment of advanced non-small cell lung cancer (NSCLC). Pemetrexed is generally well tolerated, but individual-patient differences exist in severity of adverse events.
How long is pemetrexed infusion?
Pemetrexed Lilly should be administered as an intravenous infusion over 10 minutes on the first day of each 21-day cycle.
How do you dilute ALIMTA?
An appropriate quantity of the reconstituted ALIMTA solution must be further diluted into a solution of 0.9% Sodium Chloride Injection (preservative free), so that the total volume of solution is 100 ml. ALIMTA is administered as an intravenous infusion over 10 minutes.
How long is ALIMTA infusion?
The recommended dose of ALIMTA is 500 mg/m2 administered as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle. The recommended dose of cisplatin is 75 mg/m2 infused over 2 hours beginning approximately 30 minutes after the end of ALIMTA administration.
Why do you give B12 with Alimta?
SAN FRANCISCO—Adding vitamin B12 and folic acid to chemotherapy with pemetrexed disodium (Alimta) reduces the incidence of severe life-threatening toxicities, according to research presented at the 37th Annual Meeting of the American Society of Clinical Oncology (ASCO abstract 300).
How do you reconstitute ALIMTA 500mg?
Reconstitute each 500-mg vial with 20 mL of 0.9% Sodium Chloride Injection (preservative free). Reconstitution of either size vial gives a solution containing 25 mg/mL ALIMTA. Gently swirl each vial until the powder is completely dissolved.
What’s the trade name for the drug pemetrexed?
Alimta is the trade name for generic drug name Pemetrexed. In some cases, health care professionals may use the trade name Alimta when referring to the generic drug name Pemetrexed. Drug type: Pemetrexed is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Pemetrexed is classified as an “antimetabolite.”
What should you know about pemetrexed and mefenamic acid?
If coadministration of an NSAID is necessary, closely monitor patients for toxicity, especially myelosuppression, renal toxicity, and GI toxicity. mefenamic acid increases levels of pemetrexed by unspecified interaction mechanism. Avoid or Use Alternate Drug.
What should you know about pemetrexed and aspirin rectal?
If coadministration of an NSAID is necessary, closely monitor patients for toxicity, especially myelosuppression, renal toxicity, and GI toxicity. aspirin rectal increases levels of pemetrexed by unspecified interaction mechanism.
When does ANC return to baseline after Pemetrexed exposure?
Time to ANC nadir with pemetrexed systemic exposure (AUC), varied between 8 to 9.6 days over a range of exposures from 38.3 to 316.8 mcg•hr/mL. Return to baseline ANC occurred 4.2 to 7.5 days after the nadir over the same range of exposures.