What is a benzalkonium chloride used for?
Benzalkonium chloride is a quaternary ammonium antiseptic and disinfectant with actions and uses similar to those of other cationic surfactants. It is also used as an antimicrobial preservative for pharmaceutical products [23].
How do you test for benzalkonium chloride?
The purity of benzalkonium chloride and the structural isomer distribution is determined using an HPLC system with a gradient elution mobile phase and UV detection of the eluting aromatic compounds. The water content of benzalkonium chloride is determined by Karl Fischer titration.
What is benzalkonium chloride mode of action?
Benzalkonium chloride (BAC) is a wide spectrum quaternary ammonium antibacterial agent that has been used in various dental composites. 79,80. It is cationically charged and induces antibacterial action through attraction to the negatively charged bacterial membrane.
How effective is benzalkonium chloride as an antibacterial?
Purpose : Benzalkonium chloride (BAK) is a common preservative used in ophthalmic medications and is the active ingredient in some skin disinfectants and hand sanitizers. BAK is known to be effective in killing bacteria and enveloped viruses. However, its activity against non-enveloped viruses is unknown.
What is the common name for benzalkonium chloride?
Benzalkonium chloride (BZK, BKC, BAK, BAC), also known as alkyldimethylbenzylammonium chloride (ADBAC) and by the trade name Zephiran, is a type of cationic surfactant. It is an organic salt classified as a quaternary ammonium compound.
Why is benzalkonium chloride harmful?
Clinically, benzalkonium chloride may cause eye irritation and is known to discolour soft contact lenses. Benzalkonium chloride in eye drops has also been reported to cause punctate keratopathy and/or toxic ulcerative keratopathy, especially in frequent or prolonged use or in conditions where the cornea is compromised.
What is the PH of benzalkonium chloride?
BCK specification
| Name: | Benzalkonium Chloride |
|---|---|
| Purity: | 80%,50% |
| PH value: | 6-8 |
| Appearance: | Colorless to slightly yellow Liquid. Soluble in water under normal temperature. |
| Active matter%: | 45±2 |
How long does benzalkonium chloride last on surfaces?
Benzalkonium chloride (BAC) is one of the Quats common used for surface disinfection. The study found that BAC is not degradation rapidly and its antimicrobial effect last on the surface for days [47] .
Is benzalkonium chloride used in hospitals?
It is usually applied by a health care professional in a hospital or clinic setting. If you are to use this medicine at home, use it as directed.
Is Bzk better than alcohol?
The graph demonstrates that users of alcohol had more bacteria on them than the users of BZK throughout the week. The line of best fit for the alcohol users had a rate of increase in cumulative colony counts of 11.785, whereas the BZK users rate of increase was 6.933.
How safe is benzalkonium chloride?
This cosmetic ingredient is not a sensitizer to normal humans at concentrations of 0.1%, but may be to individuals with diseased skin. It is concluded that Benzalkonium Chloride can be safely used as an antimicrobial agent at concentrations up to 0.1%.
Is benzalkonium chloride an antiseptic?
Benzalkonium chloride is a quaternary ammonium antiseptic and disinfectant with actions and uses similar to those of other cationic surfactants. It is also used as an antimicrobial preservative for pharmaceutical products.
How to test for benzalkonium chloride in water?
Standard solution— Dilute USP Benzalkonium Chloride RS with water to obtain a solution having a known concentration of about 4 mg per mL. Test solution— Dissolve about 1 g of Benzalkonium Chloride, accurately weighed, in water in a 50-mL volumetric flask, dilute with water to volume, and mix.
How to make benzalkonium chloride in a steam bath?
USP Reference standards 11— USP Benzalkonium Chloride RS . A: To a solution (1 in 100) add 2 N nitric acid or mercuric chloride TS: a white precipitate is formed, and it is soluble in alcohol. B: Dissolve about 200 mg in 1 mL of sulfuric acid, add 100 mg of sodium nitrate, and heat on a steam bath for 5 minutes.
What is the concentration of acetonitrile in benzalkonium chloride?
The acetonitrile concentration may be varied from 40 parts to 60 parts to meet system suitability requirements. Standard solution— Dilute USP Benzalkonium Chloride RS with water to obtain a solution having a known concentration of about 4 mg per mL.
How much chloroform to add to benzalkonium chloride?
Add 25 mL of chloroform, and proceed as directed in the Assay for total alkylbenzyldimethylammonium chlorides under Benzalkonium Chloride, beginning with “Add 10.0 mL of freshly prepared potassium iodide solution (1 in 20).”