What is an ALP isoenzyme test?
The ALP bone isoenzyme test is a blood test that measures the levels of ALP-2 in your bones. The test can detect abnormal levels of bone growth that may indicate a bone disease or another serious condition such as leukemia or hyperparathyroidism.
What are the isoenzymes of ALP?
Alkaline phosphatase is divided into four isozymes depending upon the site of tissue expression that are Intestinal ALP, Placental ALP, Germ cell ALP and tissue nonspecific alkaline phosphatase or liver/bone/kidney (L/B/K) ALP.
What is alkaline phosphatase bone isoenzyme raised?
Bone specific alkaline phosphatase isoenzyme is elevated as a result of increased osteoblastic activity. The highest total ALP values have been attributed to an increased bone isoenzyme level due to Paget disease or rickets/osteomalasia.
What is the clinical significance of alkaline phosphatase?
Background: Alkaline phosphatase (ALP) is an enzyme that is elevated by various hepatobiliary diseases. Generally its elevation is thought to indicate bile stasis. There are some reports that show ALP is an important prognostic factor for several cancers such as colon, lung, and gastric cancer.
What causes high liver isoenzyme?
Various liver diseases (primary or secondary cancer, biliary obstruction) increase the liver isoenzyme. Liver 1 is increased in some nonmalignant diseases (such as cholestasis, cirrhosis, viral hepatitis, and in various biliary and hepatic pathologies).
What is isoenzyme with example?
Isozymes (also known as isoenzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. The existence of isozymes permits the fine-tuning of metabolism to meet the particular needs of a given tissue or developmental stage (for example lactate dehydrogenase (LDH)). …
What is isoenzyme pattern?
In biochemistry, isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. In many cases, isozymes are encoded by homologous genes that have diverged over time.
What is intestinal isoenzyme?
Definition. Alkaline phosphatase (ALP) is an enzyme found in many body tissues such as liver, bile ducts, bone, and intestine. There are several different forms of ALP called isoenzymes. The structure of the enzyme depends on where in the body it is produced.