What drugs are MEK inhibitors?
To date, four MEK inhibitors have been approved by the United States Food and Drug Administration (FDA), including trametinib, binimetinib, selumetinib, and cobimetinib [19–22].
What are MEK inhibitors used for?
A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase kinase enzymes MEK1 and/or MEK2. They can be used to affect the MAPK/ERK pathway which is often overactive in some cancers.
Why are BRAF and MEK inhibitors given together?
In comparison with single agent BRAF inhibitors, the combination of BRAF and MEK inhibitors have shown significant improvement in response rates, PFS and OS in addition to fewer side effects related to paradoxical activation of the MAPK pathway; the combination has now become the standard of care in patients with …
What is a MEK inhibitor trametinib?
Trametinib (Mekinist™) is a reversible and highly selective allosteric inhibitor of MEK1 and MEK2 with anticancer activity against metastatic melanoma carrying the BRAF V600 mutation.
What MEK solvent?
Methyl ethyl ketone (MEK) is a colorless liquid that has a sweet odor and is soluble in water. It is a highly volatile chemical and is frequently used as a commercial cleaner and solvent for glues, paints, coatings, and printing inks.
What is Trametinib used for?
Trametinib is used alone or in combination with dabrafenib (Tafinlar) to treat a certain types of melanoma (a type of skin cancer) that cannot be treated with surgery or that has spread to other parts of the body.
What are the side effects of MEK?
MEK Inhibitor Side Effects The most common adverse effects of MEK inhibitors (e.g., trametinib) are rash, diarrhea, peripheral edema, fatigue, and dermatitis acneiform. MEK inhibitors also have unique cardiac and ophthalmologic side effects. Central serous retinopathy can occur during treatment with trametinib.
Are MEK inhibitors targeted therapy?
MEK Inhibitors Combined with BRAF Inhibitors for Metastatic Melanoma. The MEK gene has a close connection to the BRAF gene, so drugs that are targeted to MEK can also help treat melanoma with BRAF mutations. MEK inhibitors include trametinib (Mekinist®), cobimetinib (Cotellic®), and binimetinib (Mektovi®).
Is trametinib a MEK inhibitor?
What are the side effects of Mekinist?
Common side effects of TAFINLAR and MEKINIST in people with NSCLC include:
- Fever.
- Fatigue.
- Nausea.
- Vomiting.
- Diarrhea.
- Dry skin.
- Decreased appetite.
- Rash.