Is pegfilgrastim better than filgrastim?
The two pivotal non-inferiority trials, upon which licensing depended; each concluded that filgrastim and pegfilgrastim are comparable in efficacy, safety and tolerance [5, 6]. However, as the Aapro report indicates, a pooled analysis of these two trials concluded that pegfilgrastim might have superior efficacy [7].
Why is pegfilgrastim given?
Pegfilgrastim injection products are used to reduce the chance of infection in people who have certain types of cancer and are receiving chemotherapy medications that may decrease the number of neutrophils (a type of blood cell needed to fight infection).
Is there an alternative to filgrastim?
For a large healthcare system, the arrival of a cheaper alternative to filgrastim prompted the conversion to using tbo-filgrastim as the preferrred granulocyte-colony stimulating factor.
What are the side effects of filgrastim?
Filgrastim injection products may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- redness, swelling, bruising, itching or a lump in the place where the medication was injected.
- bone, joint, back, arm, leg, mouth, throat, or muscle pain.
- headache.
- rash.
- constipation.
- diarrhea.
- nausea.
What is pegfilgrastim 6mg?
USES: Pegfilgrastim is a man-made version of a certain natural substance made in your body. It is used to help your body make more white blood cells. White blood cells are important to help you fight off infections. Pegfilgrastim is given to people whose ability to make white blood cells is reduced due to chemotherapy.
Why is filgrastim given 24 hours after chemotherapy?
This medication is usually given at least 24 hours after chemotherapy to stimulate the growth of new, healthy, white blood cells (WBC). Pegfilgrastim is a longer acting form of filgrastim and the manufacturer recommends that it should not be given within 14 days prior to chemotherapy.
Does Filgrastim need to be given at the same time?
Filgrastim is most often given as a subcutaneous injection (SQ, given under the skin), but it can be given directly into a vein (intravenous, IV). It is given once a day, preferably at the same time of day, until the neutrophil count returns to normal.
Is filgrastim a chemo drug?
This medication is used to prevent infection and neutropenic (low white blood cells) fevers caused by chemotherapy. Filgrastim is a support medication. It does not treat cancer.
Which is better lipegfilgrastim or pegfilgrestim 6 mg?
Drug-related adverse events in the safety population were reported in 28% and 26% of patients in the lipegfilgrastim and pegfilgrastim groups, respectively. This study demonstrates that lipegfilgrastim 6 mg is as effective as pegfilgrastim in reducing neutropenia in patients with breast cancer receiving myelosuppressive chemotherapy.
How is lipegfilgrastim used in cancer treatment?
Lipegfilgrastim is a novel glyco-pegylated granulocyte-colony stimulating factor in development for neutropenia prophylaxis in cancer patients receiving chemotherapy.
How many mg of pegfilgrastim can a child take?
Children who weigh more than 45 kg can receive one standard 6-mg dose of pegfilgrastim. 2 Although studies on the safety and effectiveness of pegfilgrastim in pediatric patients are limited, comparisons of filgrastim with pegfilgrastim have shown similar efficacy.
Which is better for auto-SCT lipeg or peg?
Conclusion: LIPEG appears to be more efficient compared with PEG after chemotherapy to mobilize CD34+cells for auto-SCT demonstrated as fewer sessions of aphereses needed as well as 2.8-fold CD34+cell yields on the first apheresis day. Early hematologic recovery was more rapid in the LIPEG group.