What does a negative HLA B27 test mean?
A negative result mean you don’t have HLA-B27 in your blood. A positive result means HLA-B27 was found in your blood. You may have a higher-than-average risk of certain autoimmune diseases, such as ankylosing spondylitis and reactive arthritis. If you are white, you are more likely to test positive for the HLA-B27 antigens.
How many people have the HLA-B27 gene?
The HLA-B gene has many different normal variations. The type of HLA-B genes that you have depends on which individual copies of genes (alleles) you inherited from each of your parents. In the United Statesand the United Kingdom, only about 6 percent to 8 percent of the general population is HLA-B27 positive (they have the HLA-B27 gene).
Can a person with HLA B27 get ankylosing spondylitis?
HLA–B27 is a gene that is found in 4-24% of the normal population, varying according to race. Of those people who have HLA–B27, only a small proportion go on to get a disease associated with the allele. Only 3-5% of those people with HLA–B27 get Ankylosing Spondylitis.
What are the most common autoimmune disorders associated with HLA-B27?
The most common autoimmune disorders connected with HLA-B27 antigens are: 1 Ankylosing spondylitis, a form of arthritis that affects the spine 2 Juvenile arthritis, which occurs in children 3 Reactive arthritis, a type of arthritis in the joints More
Is the HLA B27 antigen found in Reiter’s disease?
HLA-B27 Antigen – HLA-B27 is found in 90% of patients with ankylosing spondylitis and 80% in Reiter’s disease. Ankylosing spondylitis affects 1 in 1000 caucasians. Ankylosing spondylitis is 10 times more common among individuals with HLA-B27 compared to individuals without this antigen.
Where are HLA-B27 antigens found in white blood cells?
Human lymphocyte antigen B27, human leukocyte A antigen, histocompatibility leukocyte A antigen What is this test? This test looks for HLA-B27, which are proteins called antigens. These are found on the surface of white blood cells that are fighting infection.
Can a person with ankylosing spondylitis test positive for HLA B27?
But almost 80-90% of people with ankylosing spondylitis are found to be positive for HLA-B27. It is also to be noted that around 10-20% of patients with proven ankylosing spondylitis will test negative for HLA B27.