Where is CEA made?
CEA is normally produced in gastrointestinal tissue during fetal development, but the production stops before birth. Consequently, CEA is usually present at very low levels in the blood of healthy adults (about 2-4 ng/mL).
What is CEA used for?
A CEA test may be used to: Monitor treatment of people with certain types of cancers. These include colon cancer and cancers of the rectum, prostate, ovary, lung, thyroid, and liver. Figure out the stage of your cancer.
What is meant by CEA?
A substance that may be found in the blood of people who have colon cancer, other types of cancer or diseases, or who smoke tobacco. CEA levels may help keep track of how well cancer treatments are working or if cancer has come back. It is a type of tumor marker. Also called carcinoembryonic antigen.
What is CEA test for cancer?
A CEA test measures the level of carcinoembryonic antigen (CEA) in your blood or other body fluid, as an indicator of whether cancer is growing and spreading or diminishing with treatment.
How is CEA produced?
CEA is a substance found on the surface of some cells. It is a type of glycoprotein produced by cells of the gastrointestinal tract during embryonic development. It is produced in very small amounts after birth.
Who discovered carcinoembryonic antigen?
Freedman, who was the director of the Division of Allergy at the MGH and subsequently dean of medicine at McGill University. In 1965 they published their discovery of the carcinoembryonic antigen (CEA), which is produced during the growth of the bowel.
What causes CEA to rise?
The most frequent cancer which causes an increased CEA is cancer of the colon and rectum. Benign conditions which can elevate CEA include smoking, infections, inflammatory bowel disease, pancreatitis, cirrhosis of the liver, and some benign tumors in the same organs in which an elevated CEA level indicates cancer.
What factors affect CEA?
In this study of CEA levels in 18,131 healthy nonsmoking individuals without malignancy or inflammatory disease, factors such as gender, age, the WBC count, BMI, HB, AST, creatinine, and HbA1c levels were found to be significant factors associated with the serum CEA level.
How can CEA be reduced?
Thus, we suggest that exercise for 2-3 days per week decreases the expression of CEA and improves body condition, without loading fatigue or stress, which may contribute to preventing cancer in the elderly women.
Where does the carcinoembryonic antigen ( CEA ) come from?
From Wikipedia, the free encyclopedia Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell adhesion. CEA is normally produced in gastrointestinal tissue during fetal development, but the production stops before birth.
What is the purpose of an anti CEA antibody?
Antibodies An anti-CEA antibody is an antibody against CEA. Such antibodies to CEA are commonly used in immunohistochemistry to identify cells expressing the glycoprotein in tissue samples.
What is the role of CEA in colon carcinoma?
CEA are glycosyl phosphatidyl inositol (GPI) cell-surface-anchored glycoproteins whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells.
What are the low levels of CEA in the blood?
Consequently, CEA is usually present at very low levels in the blood of healthy adults (about 2-4 ng/mL). However, the serum levels are raised in some types of cancer, which means that it can be used as a tumor marker in clinical tests. Serum levels can also be elevated in heavy smokers.