What receptors does succinylcholine work?
A depolarizing neuromuscular blocking agent, succinylcholine adheres with post-synaptic cholinergic receptors of the motor endplate, inducing continuous disruption that results in transient fasciculations or involuntary muscle contractions and subsequent skeletal muscle paralysis.
Does succinylcholine bind to nicotinic receptors?
Succinylcholine (suxamethonium) is a highly potent agonist at the neuromuscular junction (NMJ) nicotinic acetylcholine receptors. It is a direct cholinergic agonist in that it binds to the same binding site as the endogenous transmitter acetylcholine and activates the receptor in the same manner as acetylcholine.
Why is succinylcholine used in ECT?
Succinylcholine has been traditionally the muscle relaxant of choice for electroconvulsive therapy (ECT) owing to its rapid onset of action and ultrashort duration of effect.
Why is succinylcholine used?
Succinylcholine is a skeletal muscle relaxant for intravenous (IV) administration indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
What are the muscarinic effects of succinylcholine?
Succinylcholine can cause a rapid increase in intraocular pressure due to effects on ocular blood vessels & myofibrils. It can cause cardiac arrhythmias (increase or decrease in heart rate) because of its effects on muscarinic receptors and nicotinic-ganglionic receptors.
Is succinylcholine an antagonist or agonist?
Succinylcholine is the only therapeutically used depolarizing neuromuscular blocker. Unlike nondepolarizing substances, succinylchloride is not a competitive antagonist; conversely, it is a more stable agonist than acetylcholine.
When is succinylcholine contraindicated?
Succinylcholine is contraindicated in persons with personal or familial history of malignant hyperthermia, skeletal muscle myopathies, and known hypersensitivity to the drug.
Why does succinylcholine cause muscle relaxation?
Succinylcholine is a depolarizing skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations.
How is succinylcholine given?
Intramuscular Use. If necessary, succinylcholine may be given intramuscularly to infants, older children, or adults when a suitable vein is inaccessible. A dose of up to 3 to 4 mg/kg may be given, but not more than 150 mg total dose should be administered by this route.