What is the function of POT1?
The Protection of Telomeres 1 (POT1) protein is an essential subunit of the shelterin telomere binding complex. It directly binds to single-stranded telomeric DNA, protecting chromosomal ends from an inappropriate DNA damage response, and plays a role in telomere length regulation.
What is POT1 gene mutation?
POT1 (Protection Of Telomeres 1) is a Protein Coding gene. Diseases associated with POT1 include Melanoma, Cutaneous Malignant 10 and Glioma Susceptibility 9. Among its related pathways are Cell Cycle, Mitotic and Cellular Senescence.
What do Shelterin proteins do?
Shelterin is a six-subunit protein complex (comprising TRF1, TRF2, POT1, TPP1, TIN2 and Rap1) that associates specifically with mammalian telomeres and allows cells to distinguish the natural ends of chromosomes from sites of DNA damage. Shelterin function is crucial for telomere maintenance and genome integrity.
What is Shelterin in telomere?
Shelterin is a six-subunit protein complex (comprising TRF1, TRF2, POT1, TPP1, TIN2 and Rap1) that associates specifically with mammalian telomeres and allows cells to distinguish the natural ends of chromosomes from sites of DNA damage.
Where is the Shelterin complex?
telomeres
Shelterin is abundant at chromosome ends but does not accumulate elsewhere; it is present at telomeres throughout the cell cycle, and its known function is limited to telomeres. Non-shelterin proteins at chromosome ends fail to meet two or three of these criteria, yet can play important roles at telomeres.
What is shelterin made of?
The shelterin complex is made up of six family members that bind along the length of the telomere: TRF1 (TERF1), TRF2 (TERF2), RAP1 (TERF2IP), TIN2 (TINF2), TPP1 (ACD) and POT1 (POT1) (Fig.
What does the Shelterin complex do?
What is the purpose of the Shelterin complex?
Shelterin (also called telosome) is a protein complex known to protect telomeres in many eukaryotes from DNA repair mechanisms, as well as to regulate telomerase activity.
Do Shelterin proteins extend telomeres?
How does the Shelterin complex shelter telomeres?
Shelterin. Shelterin, as the name suggests, provides shelter to the ends of linear chromosomes by repressing DNA damage-signaling responses, masking telomeres from DNA repair machinery, and regulating the length of telomeres [7, 14].
What do shelterin proteins do?
What is the function of shelterin protein?