What is the contraindication of pethidine?
Contraindications: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1 Severe respiratory depression, severe obstructive airways disease or acute asthma. It should not be administered to patients with severe renal impairment or severe hepatic impairment.
When should you not give pethidine?
Pethidine Injection must not be used with drugs used to treat severe depression, such as rasagiline or moclobemide or if you are within 2 weeks of discontinuing them. A large number of drugs can interact with Pethidine Injection which can significantly alter their effects.
Which painkiller is safe during pregnancy?
Continued. Most pregnant women can take acetaminophen if their doctor gives them the thumbs-up. It’s the most common pain reliever that doctors allow pregnant women to take. Some studies have found that about two-thirds of pregnant women in the U.S. take acetaminophen sometime during their nine-month stretch.
Which drug should not be administered to a pregnant woman?
Ibuprofen (Motrin, Advil) Herbs, minerals, amino acids, and regular vitamins. Isotretinoin (formerly sold as Accutane, now Absorica, Amnesteem, Claravis, Myorisan, Zenatane) taken for acne. Thalidomide (Thalomid) taken for a type of skin disease and multiple myeloma.
Does pethidine affect baby?
As Pethidine is an opiate it will cross the placenta and a small amount will pass through to your baby. This can sometimes make babies sleepy when born if it’s given later on in labour, a reversal drug for your baby would then be required should this happen.
Does pethidine work labour?
Pethidine is a type of painkiller and is one of many pain relief options you have during labour.
What stage of labour can you have pethidine?
Pethidine is given during the first stage of labour, when your cervix is opening up from being tightly closed to fully dilated. This is the period before you start pushing. Your midwife may suggest a vaginal examination to see how far your cervix has dilated, before giving you pethidine.
Can pethidine cause fetal distress?
The intramuscular injection of 75 mg pethidine has a rapid onset of action with no harmful effect on the mother or her infant. It causes no fetal distress.
Which drugs cross the placenta?
Drugs which have been shown to undergo significant placental metabolism include azidothymidine, dexamethasone, and prednisolone (van der Aa et al., 1998). The anticonvulsant oxcarbazepine (but not carbamazepine) is also metabolized to some extent by the human placenta (Pienimäki et al., 1997; Myllynen et al., 1998).
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