What is MEGX?
Lidocaine Metabolite Monoethylglycinexylidide (MEGX), a product of hepatic lidocaine metabolism, is easily measured by a fluorescence polarization immune assay 15 minutes after administration of an intravenous dose of lidocaine.
What is Monoethylglycinexylidide used for?
Monoethylglycinexylidide is the primary metabolite of lignocaine formed by oxidative deethylation of lignocaine by liver cytochrome P-450 enzymes. Lignocaine is the most widely used local anaesthetic drug. It is rapidly acting and effectively absorbed from mucous membranes as a surface anaesthetic.
What is MEGX test?
The MEGX test has potential for investigating the pathogenesis of multiple organ dysfunction syndrome with regard to early hepatic functional impairment in critically ill patients after polytrauma or sepsis.
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