What is IL-10 gene?
IL10 (Interleukin 10) is a Protein Coding gene. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are TGF-Beta Pathway and Regulation of nuclear SMAD2/3 signaling.
How is IL-10 produced?
In humans, IL-10 is encoded by the IL10 gene, which is located on chromosome 1 and comprises 5 exons, and is primarily produced by monocytes and, to a lesser extent, lymphocytes, namely type-II T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and in a certain subset of activated T cells and B cells …
Is IL-10 a cytokine?
Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that plays a central role in limiting host immune response to pathogens, thereby preventing damage to the host and maintaining normal tissue homeostasis.
How is IL-10 anti-inflammatory?
IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages, all of which are required for optimal pathogen clearance but also contribute to tissue damage. In consequence, IL-10 can both impede pathogen clearance and ameliorate immunopathology.
Which cells produce IL-6?
IL-6 is a single chain glycoprotein, produced by monocytes, endothelial cells, and adipose tissue (Rattazzi et al., 2003).
Is IL-10 a Th2 cytokine?
IL-10 was originally described as a cytokine produced specifically by CD4+ Th2 cells, but later studies showed that it was secreted by both Th1 and Th2 cells. IL-10 is also made by CD4+ Foxp3+ CD25+ “natural” regulatory T (T reg) cells and IL-10–induced CD4+ T reg cells (Tr1 cells) (1).
Are there any homologs of the IL10 gene?
Homologs of the IL10 gene: The IL10 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. These reference sequences exist independently of genome builds. Explain
What is the relationship between IL-6 and IL-10?
IL-6 and IL-10 Closely Correlate with Bacterial Bloodstream Infection. Title: IL-6 and IL-10 Closely Correlate with Bacterial Bloodstream Infection. Differential IL 10 serum production between an arm-based and a leg-based maximal resistance test.
What does IL10 interleukin 10 do for the body?
It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production.
Where does IL10 bind to the JAK1 receptor?
Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed: 16982608 ). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed: 18025162 ).