What causes low osteocalcin?
Osteocalcin can be decreased by: Underactive thyroid (Hypothyroidism) [7] Underactive parathyroid gland (Hypoparathyroidism) [8] Growth hormone deficiency [9, 10]
What does osteocalcin do in the body?
Osteocalcin is a secreted factor influencing matrix mineralization and global metabolism. Osteocalcin regulates glucose metabolism via a bone-pancreas endocrine loop. New data suggests an additional role in cognition and male fertility. Clinical studies suggest a more complex role for osteocalcin in human metabolism.
What organ does osteocalcin target?
Further mechanistic investigations suggest that the target receptor of osteocalcin in the brain is the G-protein coupled receptor Gpr158.
What is high osteocalcin?
Osteocalcin levels are increased in metabolic bone diseases with increased bone or osteoid formation including osteoporosis, osteomalacia, rickets, hyperparathyroidism, renal osteodystrophy, thyrotoxicosis, and in individuals with fractures, acromegaly, and bone metastasis.
What is NTx urine test?
NTx is specific to bone and is found in urine as a stable end product of bone degradation. The NTx test measures the concentration of cross-linked N-telopeptides of type I collagen. Levels of NTx correlate with the rate of bone resorption.
Which hormone is produced by bone?
Our bones secrete a protein called osteocalcin, discovered in the 1970s, that rebuilds the skeleton. In 2007, Karsenty and colleagues discovered that this protein acts as a hormone to keep blood sugar levels in check and burn fat.
Is osteocalcin good for pregnant woman?
Consequently, osteocalcin favors postnatally, and independently of its metabolic role, several behaviors by signaling in the brain. As importantly, during pregnancy maternal osteocalcin crosses the placenta and prevents neuronal apoptosis in the embryo before it can synthesize this hormone.
What organ makes and releases the hormone osteocalcin?
The cells responsible for making bone, known as osteoblasts, produce a hormone called osteocalcin which communicates with a number of different organs, including the pancreas and brain.
Is there a link between hormonal imbalance and osteoporosis?
Bone health is difficult to maintain and can be compromised over time for many different reasons. Instead of letting the condition sneak up on you and cause injury, it is important to know the link between osteoporosis and hormonal imbalance. This is of particular pertinence to menopausal women, who are strongly affected by hormonal fluctuations.
When does osteocalcin decline in the human body?
“In the brain, it regulates the secretion of most neurotransmitters that are needed to have memory. The circulating levels of osteocalcin declines in humans around mid-life, which is roughly the time when these physiological functions, such as memory and the ability to exercise, begin to decline.”
What are the symptoms of a hormonal imbalance?
Final thoughts on hormonal imbalances. 1 Some of the most common symptoms of hormone imbalances include unexplained weight gain, fatigue,… 2 Root causes of hormonal imbalances include compromised gut health, high inflammation,… 3 Natural ways to balance your hormones include eating anti-inflammatory fats, getting adequate sleep,…
How does osteocalcin work in the endocrine system?
Importantly, osteocalcin is secreted solely by osteoblasts but only has minor effects on bone mineralization and density. Instead, it has been reported to control several physiological processes in an endocrine manner, such as glucose homeostasis and exercise capacity, brain development, cognition,…