What are the side effects of cisplatin?
Common side effects of cisplatin
- Risk of infection. This treatment can reduce the number of white blood cells in your blood.
- Bruising and bleeding.
- Anaemia (low number of red blood cells)
- Feeling sick.
- Loss of appetite.
- Changes to your taste.
- Effects on the kidneys.
- Changes in hearing.
Does cisplatin cause hypersensitivity?
The incidence of cisplatin hypersensitivity exhibits similar characteristics to those observed with carboplatin. It seems to range from 5% to 20% and increases with concomitant radiation [43].
When does cisplatin side effects start?
Nausea and vomiting usually begin within 1 to 4 hours after treatment and last up to 24 hours. Various degrees of vomiting, nausea and/or anorexia may persist for up to 1 week after treatment.
Which chemo drugs cause hypersensitivity reactions?
Hypersensitivity allergic reactions have been reported with most chemotherapy drugs, although they are generally infrequent. They occur more commonly with L-asparaginase, paclitaxel, docetaxel, teniposide, procarbazine, and cytarabine.
What are the long-term side effects of cisplatin?
One of the most common long-term side effects of Platinol (cisplatin), a medication used for many cancers including lung cancer, is hearing loss (ototoxicity). Other medications may also cause hearing loss and tinnitus (ringing in the ears).
How are chemo reactions treated?
The type of chemo drugs you use can affect your experience. Try these tips to help manage some common side effects….Fatigue
- Rest or take short naps during the day.
- Exercise. A short walk may boost your energy.
- Ask family or friends for help when you need it.
- Focus your energy on important things.
Which of the following symptoms is associated with a flare reaction?
Symptoms of a flare reaction include: Tenderness. Warmth. Redness along the vein or at the site of the injection.
How long does it take for cisplatin to leave your body?
The first elimination half-life (t1/2) for cisplatin was 5.02 months and the second 37.0 months. For oxaliplatin, these half-lifes were 1.37 and 535 months.
What are the long term side effects of cisplatin?
Can you have a severe reaction to chemo?
These reactions range from mild to life-threatening and are difficult to predict. Symptoms include flushing, nausea, difficulty breathing, back pain, hypotension and tachycardia. Hypersensitivity is commonly encountered owing to the increasing use of chemotherapy drugs in clinical practice.
Are there any side effects after stopping cisplatin?
After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects: Black, tarry stools. blood in urine or stools. convulsions (seizures) cough or hoarseness. decrease in urination.
What is the mechanism of action of cisplatin in cancer?
Its mode of action has been linked to its ability to crosslink with the purine bases on the DNA; interfering with DNA repair mechanisms, causing DNA damage, and subsequently inducing apoptosis in cancer cells.
Can a cancer patient relapse from cisplatin treatment?
Platinum responsiveness is high primarily but many cancer patients will ultimately relapse with cisplatin-resistant disease. Hence, drug resistance has been observed in many patients who have relapsed from cisplatin treatment.
How are cisplatin and carboplatin used in SCLC?
At present, platinum based treatments are key drugs for SCLC ( Abrams, Lee et al., 2003 ). Cisplatin and carboplatin are two of the most common types of platinum based treatments used in SCLC chemotherapy ( Go and Adjei, 1999 ). In clinical trials, cisplatin is often selected due to its strong antitumor activity,…