Is Pluronic a poloxamer?
Let us mention that Pluronic is a poloxamer, i.e., an amphiphilic copolymer composed of a central hydrophobic chain of polyoxypropylene (poly-propylene oxide) flanked by two hydrophilic chains of polyoxyethylene (polyethylene oxide).
What is poloxamer used for?
What is it? Poloxamers are polymers used for drug delivery as formulation excipients. They are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. They are also used in topical dosage forms and rectal suppositories.
What is Pluronic f127 used for?
Pluronic F-127 has been widely used in drug delivery, controlled release, and MSC encapsulation applications [34]. The thermosensitive properties of Pluronic F-127 make it an attractive biomaterial for regenerative applications in dentistry or medicine.
What is poloxamer made of?
Poloxamer is an amphiphilic block copolymer, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethyelene oxide) triblock copolymer (PEO-PPO-PEO) as shown in Figure 32.
What is poloxamer 184?
Poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer. It is a surfactant functioning both as cleansing and solubilizing agent.
Is poloxamer 184 toxic?
Poloxamer 184 is one of many types of surfactants used in these products. This substance is thought to be associated with moderate toxicity of non-reproductive organs, but little research suggests that it has any effect beyond mild skin irritation.
How do you make Pluronic gel?
Preparation of gel Briefly, F127 (1.8 g) was added to 10 mL PBS (pH 7.4) aqueous solution in flat-bottomed screw-capped glass vials, and gently mixed with magnetic stirrers for 24 hours at 4°C until all of the Pluronic granules were completely dissolved and a clear solution was obtained.
What is Pluronic F68?
Gibco® Pluronic® F-68 is a non-ionic surfactant used to control shear forces in suspension cultures. Pluronic® F-68 can also be used to reduce foaming in stirred cultures and reduce cell attachment to glass. Pluronic® F-68 is provided at a concentration of 10% and effective at a working concentration of 0.1%.
How do you use Pluronic?
Dissolve 2 g of Pluronic F-127 in 10 mL of anhydrous dimethylsulfoxide (DMSO) to give a 20% (w/v) stock solution. This may require heating at ~40° for about 20 minutes. Store both solid and solution at room temperature. Do not refrigerate or freeze the solutions because Pluronic F-127 may come out of solution.
Is poloxamer 184 harmful?
Poloxamer 184 This substance is thought to be associated with moderate toxicity of non-reproductive organs, but little research suggests that it has any effect beyond mild skin irritation.
What kind of copolymer is Pluronic F 108?
Pluronic® F-108 (Synperonic® F 108, Poloxamer 188) surfactant. Poloxamer 188, Surfactant is a nonionic triblock copolymer. It is made up of a main hydrophobic chain of polyoxypropylene bordered on each side by two hydrophilic chains of polyoxyethylene. Ungraded products supplied by Spectrum are indicative of a grade suitable for general
What kind of chain is poloxamer 184 made up of?
It is made up of a main hydrophobic chain of polyoxypropylene bordered on each side by two hydrophilic chains of polyoxyethylene. Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.
What are the different types of Pluronic block copolymers?
The class of ABA triblock copolymers commercially available as Pluronic® (non-proprietary name “poloxamers”) offers a pool of more than 50 amphiphilic, 10 water-soluble and polymorphic materials (A = hydrophilic block poly (ethylene oxide) (PEO) and B = hydrophobic block poly (propylene oxide) (PPO); Fig. 1 ).
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