Can varicella zoster cause encephalitis?
Varicella zoster virus in the adult patient most commonly presents as shingles. Shingles is a painful vesicular eruption localized to a specific dermatome of the body. One of the potential complications of this infection is involvement of the central nervous system causing encephalitis.
What is varicella zoster encephalitis?
Overview. VZV encephalitis is a viral infection of the central nervous system. Based on the duration of symptoms, VZV encephalitis may be classified into either acute or chronic. The exact pathogenesis of VZV encephalitis is not fully understood.
What causes reactivation of varicella zoster virus?
The primary factors that impact a person’s cellular immunity are age and medical conditions or medications that suppress the immune system. Post-pregnancy and menopausal hormonal fluctuations in women have also been linked to VZV reactivation.
How is shingles encephalitis diagnosed?
The diagnosis of herpes zoster virus encephalitis is based on clinical history, examination, neuroradiological imaging (magnetic resonance imaging and/or computed tomography scan), cerebrospinal fluid analysis and identification of the pathogen in cerebrospinal fluid by polymerase chain reaction amplification and/or …
How does VZV enter the body?
It is caused by varicella-zoster virus (VZV), which enters the body through the mouth and nose after contact with an infected person. A person with chickenpox can spread the disease to someone else from one day before the rash appears until all chickenpox blisters have crusted over.
Where does VZV lie dormant?
The varicella zoster virus lies dormant in the cranial and spinal nerves. When the virus is reactivated, it travels along the affected nerves to the area of the skin served by those nerves, where it causes a distinctive, stripe-like rash.
What is the most common cause of encephalitis?
The most common causes of viral encephalitis are herpes simplex virus types 1 and 2, varicella zoster virus and enteroviruses, which cause gastrointestinal illness. Encephalitis can also result from certain viruses carried by mosquitoes, ticks and other insects or animals such as: West Nile virus.
What organs are affected by VZV?
VZV enters the host through the respiratory tract and conjunctiva. It replicates at the site of entry in the nasopharynx and in regional lymph nodes. A primary viremia occurs 4 to 6 days after infection and disseminates the virus to other organs, such as the liver, spleen, and sensory ganglia.
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