Which form of B12 is involved in the conversion of propionyl-CoA to succinyl-CoA?
Therefore, odd-number chains of fatty acids are oxidized to yield both propionyl-CoA as well as acetyl-CoA. Propionyl-CoA is later converted into succinyl-CoA through biotin-dependant propionyl-CoA carboxylase (PCC) and b12-dependant methylmalonyl-CoA mutase (MCM), sequentially.
How is succinyl-CoA generated?
Succinyl CoA can be formed from methylmalonyl CoA through the utilization of deoxyadenosyl-B12 (deoxyadenosylcobalamin) by the enzyme methylmalonyl-CoA mutase. This reaction, which requires vitamin B12 as a cofactor, is important in the catabolism of some branched-chain amino acids as well as odd-chain fatty acids.
How is propionyl-CoA converted to succinyl-CoA?
The oxidation of the side chain of cholesterol also yields propionyl-CoA. Thus, propionyl-CoA is derived from the catabolism of lipids and proteins. Propionyl-CoA is converted to succinyl-CoA, which is oxidized or converted to glucose by way of oxaloacetate and pyruvate (gluconeogenesis; Chapter 14).
What is produced when succinyl-CoA is changed to succinate?
The process of Kreb Cycle is completed in several different steps. The conversion of succinyl CoA into succinic acid involves the removal of the CoA enzyme and the step produces energy in the form of GTP. This step produces ATP in plants.
How is propionyl CoA converted to succinyl-CoA?
What converts propionyl CoA to Succinyl?
Propionyl-CoA carboxylase (PCC) catalyzes the conversion of propionyl-CoA to methylmalonyl-CoA, which enters the Krebs cycle via succinyl-CoA. Sources of propionate include: valine, isoleucine, threonine, methionine, odd-chain fatty acids, and cholesterol.
How many NADH molecules are generated from two molecules entering the TCA cycle?
three NADH molecules
Products of the Citric Acid Cycle Each turn of the cycle forms three NADH molecules and one FADH2 molecule. These carriers will connect with the last portion of aerobic respiration to produce ATP molecules.
How does propionyl-CoA enters into TCA cycle?
Metabolic pathway. Propionyl-CoA carboxylase (PCC) catalyzes the conversion of propionyl-CoA to methylmalonyl-CoA, which enters the Krebs cycle via succinyl-CoA. Sources of propionate include: valine, isoleucine, threonine, methionine, odd-chain fatty acids, and cholesterol.