What is the function of CCL5?
Function. CCL5 is an 8kDa protein classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites.
What does high CCL5 mean?
Abstract. We found that high levels of serum C‐C motif chemokine ligand 5 (CCL5), a chemokine produced by immune cells, were significantly associated with improved prognosis of patients with operated breast cancer.
What is rantes cytokine?
RANTES (Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted) is a chemokine secreted by platelets that have been activated predominantly during flow conditions. 118–121. This chemokine interacts with P-selectin in mediating monocyte/macrophage infiltration into atherosclerotic lesions.
Is CCR5 on T cells?
C-C chemokine receptor 5 (CCR5) is expressed on a number of cells, including T lymphocytes, macrophages, and dendritic cells (1), and is a receptor for the β-chemokines chemokine ligand (CCL)-3 (MlP-lα), CCL4 (MIP-lβ), and CCL5 (RANTES), and is the major coreceptor for HIV-1 entry (2–4).
Where is CCL5 produced?
CCL5 expression is induced by IFN-γ, TNFα, or IL-1 in T cells, fibroblasts, macrophages, epithelial cells, and endothelial cells. In addition, CCL5 protein is found in eosinophil granules and is released upon exposure to IFN-γ.
What is a rantes disease?
CCL5/RANTES is a key proinflammatory chemokine produced by virus-infected epithelial cells and present in respiratory secretions of asthmatics.
What is MIP3A?
Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils.
What does the CCR5 receptor do?
CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor (GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes, macrophages, and immature dendritic cells.
Do B cells express CXCR4?
Activated B cells, on the other hand, up-regulate CCR7 expression and thus acquire the capacity to migrate into the T cell zone and to follicles in Peyer’s patches, where the CCR7 ligands, CCL19 and CCL21, are highly expressed (18, 20). CXCR4 is expressed by all subsets of B cells throughout B cell ontogeny.