What is immunotactoid glomerulonephritis?
Disease definition. Immunotactoid glomerulopathy (ITG) is a very rare condition characterized by glomerular accumulation of microtubules in the mesangium and the glomerular basement membrane, that mainly presents with proteinuria, micro-hematuria, nephrotic syndrome, renal insufficiency and hematologic malignancy.
What is Immunotactoid?
What is Immunotactoid Glomerulopathy? Immunotactoid glomerulopathy is a disease process which interferes with the normal function of your kidneys. The name comes from “immuno” which means related to the immune system, and “tactoid” which means a group of rod-like structures.
What is fibrillary Glomerulopathy?
Fibrillary and immunotactoid glomerulopathies are rare conditions defined pathologically by organized deposition of nonamyloid microfibrillar or microtubular structures within the renal mesangium and basement membrane.
How rare is fibrillary glomerulonephritis?
FGN is a rare glomerular deposition disease and accounts for approximately 0.5–1.0% of all adult glomerulonephritis cases on renal biopsy [3-6]. It is characterized by the deposition of microfibrils – 10–30 nm in diameter – in the mesangial and/or glomerular capillary walls.
What is the difference between Glomerulopathy and glomerulonephritis?
Glomerulopathy is any disease of these glomeruli. Glomerulonephritis is the result of infection elsewhere in the body, such as strep throat/scarlet fever, upper respiratory infection or tonsillitis.
What is FGN disease?
Fibrillary glomerulonephritis (FGN) is a rare idiopathic condition linked to malignancy, autoimmune disorders, monoclonal gammopathies and hepatitis C virus. It usually has a poor prognosis, resulting in progression to end-stage renal disease within a few years, given the lack of standardized treatment.
What is FGN medical?
Fibrillary glomerulonephritis (FGN) is a rare proliferative form of glomerular disease characterized by randomly oriented fibrillar deposits with a mean diameter of 20 nm.
Why does edema occur in glomerulonephritis?
As your kidneys get worse, extra fluids and salt build up in your body. This causes you to have swelling (edema), high blood pressure and higher levels of cholesterol.
Can a kidney transplant cure kidney disease?
Kidney transplantation can treat advanced kidney disease and kidney failure, but it is not a cure. Some forms of kidney disease may return after transplant.