What is CK7 positive in lung cancer?
CK7 can be specifically expressed in certain cancers, which has been verified to be expressed in lung cancer of the present study; besides, the expression of CK7 is a sign of dedifferentiation, positive cells of CK7 may therefore be relatively lower differentiation cells with high degree of malignancy.
What does CK7 mean in cancer?
Cytokeratin 7 (CK7) is a type II basic low molecular weight cytokeratin that is found in simple epithelia in a variety of organs, including all epithelia in the female genital tract. 305,306. Epithelial tumors of the ovary and fallopian tube all exhibit cytoplasmic and/or membrane staining for CK7. 307-309.
Is CK7 positive in squamous cell carcinoma?
CK5 is also highly specific for squamous cell carcinoma. Although CK20 positivity may be seen in pulmonary adenocarcinomas—in combination with negative staining for TTF1 and NAPA in rare cases—CK7 is always positive.
What type of cancer is lung adenocarcinoma?
Lung adenocarcinoma is a subtype of non-small cell lung cancer (NSCLC)A group of lung cancers that are named for the kinds of cells found in the cancer and how the cells look under a microscope. Lung adenocarcinoma is categorized as such by how the cancer cells look under a microscope.
Does CK7 positive mean cancer?
According to the criteria by Harbaum L [16], the immunoreactivity of CK7 was categorized as ‘negative’ (no tumor cells positive), ‘focal’ (<10% of tumor cells positive), ‘moderate’ (10-50%) or ‘extensive’ (>50%). Distinct cytoplasmic immunoreactivity of CK7 was considered positive.
What is p40 positive?
P40, an isoform of p63 (deltaNp63), is a highly sensitive and specific marker of SCC. In previous reports, both the sensitivity and specificity of p40 for diagnosing pulmonary SCC have been almost 100%. 3-5 Thus, p40 is known as the best marker of this cancer.
Is there a link between CK20 and adenocarcinoma?
A combination of TTF-1+CK7 CK20–was highly significantly associated with primary adenocarcinoma of lung (vs GI tract,p < 0.001; vs breast, p < 0.001). A combination of TTF-1–CKCK20+was highly significantly associated with adenocarcinoma of GI origin (vs lung,p < 0.001; vs breast, p < 0.001). Our study has confirmed that expression of CK7, CK20,
What is the role of TTF-1, CK20, and CK20?
The expression of TTF-1, CK7, and CK20 was assessed by immunohistochemistry. We found that 73% of primary lung adenocarcinomas expressed TTF-1, whereas all nonpulmonary adenocarcinomas lacked TTF-1 staining. CK7 expression was significantly more frequent in adenocarcinomas of pulmonary and breast origin than gastrointestinal (GI) origin
Which is the best immunohistochemical marker for lung adenocarcinoma?
A review of recent studies reveals that the immunohistochemical markers surfactant protein-B, PE-10, thyroid transcription factor-1 (TTF-1), cytokeratin 20 (CK20), and cytokeratin 7 (CK7) have efficacy for discriminating between primary and metastatic pulmonary adenocarcinoma [1–5].
Where are CK7 and CK20 located in the body?
Although both CK7 and CK20 are intermediate filaments, they are located in different epithelial cells. CK7, a 54-kDa basic protein, is typically located in epithelia from lung and breast; CK20]