What drugs can cause VFIB?
Antibiotics (eg, intravenous erythromycin, sulfamethoxazole/trimethoprim) Chemotherapeutics (eg, pentamidine, anthracycline) Serotonin antagonists (eg, ketanserin, zimeldine) Organophosphorus insecticides.
What medications cause polymorphic ventricular tachycardia?
These include primarily the antiarrhythmic drugs (IA, IC, sotalol and bepridil), digitalis, sympathomimetics and phosphodiesterase inhibitors.
Which drugs are Proarrhythmic?
Cardiac glycosides, QT-prolonging agents, and sodium channel–blocking drugs have all been implicated in this proarrhythmic category. In addition, certain drugs can cause a cardiomyopathy that ultimately leads to ventricular tachyarrhythmias, specifically ventricular tachycardia (VT).
Can beta blockers cause VFIB?
Untreated patients receiving beta-blockers were more likely to have VF, but less likely to be prescribed an ACE inhibitor, digoxin or sotalol compared with patients not receiving amiodarone, an ICD or beta-blocker.
What causes VFIB?
A heart that has been damaged by a heart attack or other heart muscle damage is vulnerable to V-fib. Other causes include electrolyte abnormalities such as low potassium, certain medicines, and certain genetic diseases that affect the heart’s ion channels or electrical conduction.
What medications can affect heart rhythm?
Many medicines and drugs can affect the rate and rhythm of the heart….A few examples are:
- Asthma medicines.
- Decongestants and cold medicines.
- Illegal drugs such as cocaine or amphetamines.
- Some heart and blood pressure medicines.
- Some medicines for depression and anxiety.
- Thyroid medicine.
What drug should be avoided in ventricular arrhythmias?
Flecainide (Tambocor) Flecainide carries a US Food and Drug Administration (FDA) black box warning regarding increased mortality when the drug is used in ischemic cardiomyopathy patients. Consequently, the use of flecainide is avoided in patients with structural heart disease.
What is proarrhythmic risk?
Drug-induced proarrhythmia is defined as the occurrence of potentially lethal arrhythmias as a result of previous or concomitant pharmacological treatment. Various cardiovascular or noncardiovascular drugs can induce proarrhythmic adverse effects.
What does proarrhythmic risk mean?
Proarrhythmia is a new or more frequent occurrence of pre-existing arrhythmias, paradoxically precipitated by antiarrhythmic therapy, which means it is a side effect associated with the administration of some existing antiarrhythmic drugs, as well as drugs for other indications.
Does metoprolol stop ventricular tachycardia?
Metoprolol (200 mg/day) resulted in suppression of 60% of total premature ventricular beats, with couplets (pairs) and ventricular tachycardia decreased 84% and 94%, respectively (all p less than 0.01). Exercise-induced premature ventricular beats, especially ventricular tachycardia, were effectively suppressed.
Can metoprolol be used for ventricular tachycardia?
Arrhythmias: bisoprolol and metoprolol succinate are often preferred. Beta-blockers are the first-line treatment for long-term symptomatic rate control in patients with a range of cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia.