What does osteoblast activity mean?
An osteoblast is a cell that develops bone. Bone mass is maintained by a balance between the activity of osteoblasts that form bone and other cells called osteoclasts that remove bone.
What is ossification What is the role of the osteoblasts and osteoclasts?
Osteoblasts penetrate the disintegrating cartilage and replace it with spongy bone. This forms a primary ossification center. Ossification continues from this center toward the ends of the bones. After spongy bone is formed in the diaphysis, osteoclasts break down the newly formed bone to open up the medullary cavity.
What is the difference between an Osteocyte an osteoblast and an osteoclast?
The key difference between osteoblasts and osteocytes is that osteoblasts are a type of bone cells responsible for the formation of new bones while osteocytes are a type of bone cells that maintain the bone mass. On the other hand, osteoclasts are responsible for the resorption of the bone.
What is an osteoclast cell?
osteoclast, large multinucleated cell responsible for the dissolution and absorption of bone. Osteoclasts are formed by the fusion of many cells derived from circulating monocytes in the blood. These in turn are derived from the bone marrow. Osteoclasts may have as many as 200 nuclei, although most have only 5 to 20.
What is the role of osteoclast?
OCPs not only respond to TNF, they and osteoclasts also secrete TNF and other cytokines, such as IL-6 and IL-1 (37,38). Secretion of these cytokines is increased in response to TNF (39).
What role do osteoblasts and osteoclast perform in bone homeostasis?
Bone homeostasis is maintained by a balance between bone resorption by osteoclasts and bone formation by osteoblasts. During the processes, pro-inflammatory cytokines such as IL-1 and TNF-alpha, cause an imbalance in bone metabolism, by favoring bone resorption via the induction of RANKL and ICAM-1 on osteoblasts.
What osteoclast means?
An osteoclast is a specialized cell that absorbs and removes bone, allowing for the development of new bone and maintenance of bone strength.
What is the function of osteoclast?
Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity. They are derived from precursors in the myeloid/ monocyte lineage that circulate in the blood after their formation in the bone marrow.
What is osteoclast used for?
Anatomical terms of microanatomy An osteoclast (from Ancient Greek ὀστέον (osteon) ‘bone’, and κλαστός (clastos) ‘broken’) is a type of bone cell that breaks down bone tissue. This function is critical in the maintenance, repair, and remodeling of bones of the vertebral skeleton.